2-Phenylbutyraldehyde

Base Information

• Chemical Name: 2-Phenylbutyraldehyde
• CAS No.: 2439-43-2
• Molecular Formula: C10H12 O
• Molecular Weight: 148.205
• Hs Code.: 2912299000
• Mol file: 2439-43-2.mol

Synonyms:Butyraldehyde,2-phenyl- (6CI,7CI,8CI); (?à)-2-Phenylbutanal; 2-Phenylbutanal; 2-Phenylbutyraldehyde; NSC 37492; a-Ethylbenzeneacetaldehyde; a-Phenylbutyraldehyde

Chemical Property of 2-Phenylbutyraldehyde

Chemical Property:

• Vapor Pressure: 0.104mmHg at 25°C
• Boiling Point: 222.1°Cat760mmHg
• Flash Point: 96.7°C
• PSA: 17.07000
• Density: 0.966g/cm³
• LogP: 2.37910
• Solubility.: Dichloromethane, Ether, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

2-Phenylbutyraldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Phenylbutyraldehyde_x000D__x000D_DISCONTINUED (cas# 2439-43-2) is a compound useful in organic synthesis.

Technology Process of 2-Phenylbutyraldehyde

There total 47 articles about 2-Phenylbutyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-phenylbutan-1-ol (2035-94-1,89104-46-1) → (2RS)-2-phenylbutanal (2439-43-2)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/ejoc.200700041

Reference yield: 92.8%

1-phenylpropene (637-50-3) + carbon monoxide (201230-82-2) → 2-benzylpropionaldehyde (5445-77-2) + (2RS)-2-phenylbutanal (2439-43-2)

Guidance literature:

With hydrogen; carbonylhydridetris(triphenylphosphine)rhodium(I); In benzene; at 90 ℃; for 48h; under 76000 Torr;

Reference yield: 82.7%

3-ethyl-3,4-diphenyl-4-(trifluoromethyl)oxetan-2-one → (2RS)-2-phenylbutanal (2439-43-2)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol901290z

upstream raw materials:

ethylmagnesium iodide

1-phenyl-2-hydroxyethanone

bromobenzene

α-bromobutyraldehyde diethyl acetal

Downstream raw materials:

erythro-3-phenylpentan-2-ol

threo-3-phenylpentan-2-ol

(3,3-Dibromo-1-ethyl-allyl)-benzene

3-Phenyl-penten-2-ol

Refernces

• 1、 Yang, Jianping,Massaro, Luca,Krajangsri, Suppachai,Singh, Thishana,Su, Hao,Silvi, Emanuele,Ponra, Sudipta,Eriksson, Lars,Ahlquist, M?rten S. G.,Andersson, Pher G.. "Combined Theoretical and Experimental Studies Unravel Multiple Pathways to Convergent Asymmetric Hydrogenation of Enamides". supporting information. p. 21594 - 21603. Retrieved 2021/12/27.
• 2、 Kaicharla, Trinadh,Ngoc, Trung Tran,Teichert, Johannes F.,Tzaras, Dimitrios-Ioannis,Zimmermann, Birte M.. "A Bifunctional Copper Catalyst Enables Ester Reduction with H2: Expanding the Reactivity Space of Nucleophilic Copper Hydrides". supporting information. p. 16865 - 16873. Retrieved 2021/10/20.