1-(3-fluoro-5-(trifluoromethyl)phenyl)-1-(6-methoxypyridin-2-yl)-2-phenylethanamine

Base Information

Chemical Name:1-(3-fluoro-5-(trifluoromethyl)phenyl)-1-(6-methoxypyridin-2-yl)-2-phenylethanamine
CAS No.:939426-22-9
Molecular Formula:C₂₁H₁₈F₄N₂O
Molecular Weight:390.38
Hs Code.:

Synonyms:1-(3-fluoro-5-(trifluoromethyl)phenyl)-1-(6-methoxypyridin-2-yl)-2-phenylethanamine

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Chemical Property of 1-(3-fluoro-5-(trifluoromethyl)phenyl)-1-(6-methoxypyridin-2-yl)-2-phenylethanamine

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Technology Process of 1-(3-fluoro-5-(trifluoromethyl)phenyl)-1-(6-methoxypyridin-2-yl)-2-phenylethanamine

There total 1 articles about 1-(3-fluoro-5-(trifluoromethyl)phenyl)-1-(6-methoxypyridin-2-yl)-2-phenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.7%

: 40473-07-2
6-bromo-2-methoxypyridine

: 149793-69-1
3-fluoro-5-trifluoromethyl-benzonitrile

: 6921-34-2
benzylmagnesium chloride

: 939426-22-9
1-(3-fluoro-5-(trifluoromethyl)phenyl)-1-(6-methoxypyridin-2-yl)-2-phenylethanamine

Guidance literature:: 6-bromo-2-methoxypyridine; With n-butyllithium; In hexanes; diethyl ether; at -45 - -35 ℃; for 0.333333h;

3-fluoro-5-trifluoromethyl-benzonitrile; In hexanes; diethyl ether; at -78 - -70 ℃; for 1h;

benzylmagnesium chloride; With sodium hydroxide; chloro-trimethyl-silane; sodium hydrogencarbonate; more than 3 stages;