40473-07-2

Basic information

• Product Name: 2-Bromo-6-methoxypyridine
• Synonyms: 2-Bromo-6-methoxypyridine ,98%;2-Bromo-6-methoxy-pyridine ,97%;2-Bromo-6-methoxypyrimidine ,98%;6-BroMo-2-Methoxypyridine;Pyridine, 2-broMo-6-Methoxy-;2-Methoxy-6-broMopyridine;NSC 84173;2-Bromo-6-(methyloxy)pyridine
• CAS NO: 40473-07-2
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.02
• EINECS: 1312995-182-4
• Product Categories: Heterocycle-Pyridine series;alkyl bromide;compounds of pyridine;blocks;Bromides;Pyridines;Heterocyclic Series;Halides;Pyridine;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 40473-07-2.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 206 °C(lit.)
• Flash Point: 220 °F
• Appearance: Clear colorless to golden/Liquid
• Density: 1.53 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00298mmHg at 25°C
• Refractive Index: n20/D 1.559(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -1.04±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-6-methoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-methoxypyridine(40473-07-2)
• EPA Substance Registry System: 2-Bromo-6-methoxypyridine(40473-07-2)

Safety Data

• Hazard Codes: Xi,T,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 40473-07-2(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow liquid

InChI:InChI=1/C5H5BrN2O/c1-9-4-2-3-7-5(6)8-4/h2-3H,1H3

Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 27992-32-1 6-bromo-2-pyridone 
• 74-88-4 methyl iodide 

Downstream Products

• 54221-96-4 6-methoxypyridine-2-carbaldehyde 
• 182275-70-3 2-iodo-6-methoxypyridine 
• 128612-43-1 5,5'-Bis(methoxycarbonyl)-3,3'-bipyridine 
• 321535-19-7 6-methoxy-[2,3']bipyridinyl-5'-carboxylic acid methyl ester 
• 17920-35-3 2-amino-6-methoxypyridine 
• 415679-58-2 (6-methoxypyridin-2-yl)(6-phenylpyridin-2-yl)pyridin-2-ylmethanol 
• 372963-51-4 (6-methoxypyridin-2-yl)boronic acid 
• 174092-77-4 4-Ethyl-8-methoxy-6-trimethylsilanyl-1H-pyrano[3,4-c]pyridine 
• 174092-78-5 (S)-(+)-4-ethyl-4-hydroxy-8-methoxy-6-(trimethylsilyl)-1,4-dihydro-3H-pyrano[3,4-c]pyridin-3-one 
• 174092-76-3 3-(2-butenyloxymethyl)-4-iodo-2-methoxy-6-trimethylsilylpyridine 
• 869856-77-9 tris-(3-(6-methoxy-2-pyridyl)-benzyl)-methane 
• 74677-60-4 (6-methoxy-pyridin-2-yl)-hydrazine 
• 909720-21-4 2,3-dibromo-6-methoxypyridine 
• 1093416-70-6 1-benzenesulfonyl-2-(6-methoxypyridin-2-yl)-1H-indole 

Relevant articles and documents

A molecular brake

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NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS

The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.

Synthesis and structure-activity relationships of amide derivatives of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetic acid as selective arginine vasopressin V2 receptor agonists

A series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives was synthesized, and their structure-activity relationships were examined in order to identify potent and selective arginine vasopressin V2 receptor agonists. Attempts to substitute other chemical groups in place of the 2-pyridilmethyl moiety of 1a led to the discovery that potent V2 binding affinity could be obtained with a wide range of functional groups. This structural tolerance allowed for the manipulation of other attributes, such as selectivity against V1a receptor affinity or avoidance of the undesirable inhibition of cytochrome P450 (CYP), without losing potent affinity for the V2 receptor. Some representative compounds obtained in this study were also found to decrease urine volume in awake rats.