3-<3,5-bis(trifluoromethyl)benzyl>-5-(indol-3-ylmethylene)imidazolidine-2,4-dione

Base Information

• Chemical Name: 3-<3,5-bis(trifluoromethyl)benzyl>-5-(indol-3-ylmethylene)imidazolidine-2,4-dione
• CAS No.: 161512-55-6
• Molecular Formula: C₂₁H₁₅F₆N₃O₂
• Molecular Weight: 455.359

Synonyms:3-<3,5-bis(trifluoromethyl)benzyl>-5-(indol-3-ylmethylene)imidazolidine-2,4-dione

Chemical Property of 3-<3,5-bis(trifluoromethyl)benzyl>-5-(indol-3-ylmethylene)imidazolidine-2,4-dione

Chemical Property:

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Technology Process of 3-<3,5-bis(trifluoromethyl)benzyl>-5-(indol-3-ylmethylene)imidazolidine-2,4-dione

There total 1 articles about 3-<3,5-bis(trifluoromethyl)benzyl>-5-(indol-3-ylmethylene)imidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,1'-carbonyldiimidazole (530-62-1) + L-tryptophan 3,5-bis(trifluoromethyl)benzylamide hydrochloride → 3-<3,5-bis(trifluoromethyl)benzyl>-5-(indol-3-ylmethylene)imidazolidine-2,4-dione (161512-55-6)

Guidance literature:

With triethylamine; In dichloromethane; for 16h;

DOI:10.1021/jm00006a011

Reference yield:

3-<3,5-bis(trifluoromethyl)benzyl>-5-(indol-3-ylmethylene)imidazolidine-2,4-dione (161512-55-6) + methyl iodide (74-88-4) → 1-methyl-3-<3,5-bis(trifluoromethyl)benzyl>-5-(indol-3-ylmethylene)imidazolidine-2,4-dione

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexanes, -78 deg C, 15 min, 2.) THF, hexanes, reflux, 3 h;

DOI:10.1021/jm00006a011

upstream raw materials:

1,1'-carbonyldiimidazole

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