1-[6-deoxy-6-diethylphosphono-β-D-allofuranosyl]-5-(2-(E)-phenylvinyl)-uracil

Base Information

Chemical Name:1-[6-deoxy-6-diethylphosphono-β-D-allofuranosyl]-5-(2-(E)-phenylvinyl)-uracil
CAS No.:1601493-97-3
Molecular Formula:C₂₂H₂₉N₂O₉P
Molecular Weight:496.454
Hs Code.:

Synonyms:1-[6-deoxy-6-diethylphosphono-β-D-allofuranosyl]-5-(2-(E)-phenylvinyl)-uracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[6-deoxy-6-diethylphosphono-β-D-allofuranosyl]-5-(2-(E)-phenylvinyl)-uracil

Chemical Property:

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Technology Process of 1-[6-deoxy-6-diethylphosphono-β-D-allofuranosyl]-5-(2-(E)-phenylvinyl)-uracil

There total 3 articles about 1-[6-deoxy-6-diethylphosphono-β-D-allofuranosyl]-5-(2-(E)-phenylvinyl)-uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 6783-05-7
trans-2-phenylvinylboronic acid

: 1601493-88-2
1-[6-deoxy-6-diethylphosphono-β-D-allofuranosyl]-5-iodo-uracil

: 1601493-97-3
1-[6-deoxy-6-diethylphosphono-β-D-allofuranosyl]-5-(2-(E)-phenylvinyl)-uracil

Guidance literature:: With sodium tetrachloropalladate(II); potassium hydroxide; 5,10,15,20-tetrakis-(4-sulfonatophenyl)porphyrin; In water; N,N-dimethyl-formamide; at 100 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.02.055

Reference yield:

: 1601493-86-0
1-[3-O-benzoyl-6-deoxy-2,5-O-diacetyl-6-diethylphosphono-β-D-allofuranosyl]-5-iodo-uracil

: 1601493-97-3
1-[6-deoxy-6-diethylphosphono-β-D-allofuranosyl]-5-(2-(E)-phenylvinyl)-uracil

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / methanol / 20 °C

2: potassium hydroxide; sodium tetrachloropalladate(II); 5,10,15,20-tetrakis-(4-sulfonatophenyl)porphyrin / water; N,N-dimethyl-formamide / 100 °C / Inert atmosphere

With sodium tetrachloropalladate(II); ammonia; potassium hydroxide; 5,10,15,20-tetrakis-(4-sulfonatophenyl)porphyrin; In methanol; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.02.055

Reference yield:

: 934339-37-4
C₂₅H₃₁N₂O₁₂P

: 1601493-97-3
1-[6-deoxy-6-diethylphosphono-β-D-allofuranosyl]-5-(2-(E)-phenylvinyl)-uracil

Guidance literature:: Multi-step reaction with 3 steps

1: Iodine monochloride / dichloromethane / 15 h / Reflux

2: ammonia / methanol / 20 °C

3: potassium hydroxide; sodium tetrachloropalladate(II); 5,10,15,20-tetrakis-(4-sulfonatophenyl)porphyrin / water; N,N-dimethyl-formamide / 100 °C / Inert atmosphere

With sodium tetrachloropalladate(II); ammonia; Iodine monochloride; potassium hydroxide; 5,10,15,20-tetrakis-(4-sulfonatophenyl)porphyrin; In methanol; dichloromethane; water; N,N-dimethyl-formamide; 3: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.02.055