1-[3-O-benzoyl-6-deoxy-2,5-O-diacetyl-6-diethylphosphono-β-D-allofuranosyl]-5-iodo-uracil

Base Information

Chemical Name:1-[3-O-benzoyl-6-deoxy-2,5-O-diacetyl-6-diethylphosphono-β-D-allofuranosyl]-5-iodo-uracil
CAS No.:1601493-86-0
Molecular Formula:C₂₅H₃₀IN₂O₁₂P
Molecular Weight:708.398
Hs Code.:

Synonyms:1-[3-O-benzoyl-6-deoxy-2,5-O-diacetyl-6-diethylphosphono-β-D-allofuranosyl]-5-iodo-uracil

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Chemical Property of 1-[3-O-benzoyl-6-deoxy-2,5-O-diacetyl-6-diethylphosphono-β-D-allofuranosyl]-5-iodo-uracil

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Technology Process of 1-[3-O-benzoyl-6-deoxy-2,5-O-diacetyl-6-diethylphosphono-β-D-allofuranosyl]-5-iodo-uracil

There total 1 articles about 1-[3-O-benzoyl-6-deoxy-2,5-O-diacetyl-6-diethylphosphono-β-D-allofuranosyl]-5-iodo-uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 934339-37-4
C₂₅H₃₁N₂O₁₂P

: 1601493-86-0
1-[3-O-benzoyl-6-deoxy-2,5-O-diacetyl-6-diethylphosphono-β-D-allofuranosyl]-5-iodo-uracil

Guidance literature:: With Iodine monochloride; In dichloromethane; for 15h; Reflux;
DOI:10.1016/j.ejmech.2014.02.055

Reference yield:

: 1601493-86-0
1-[3-O-benzoyl-6-deoxy-2,5-O-diacetyl-6-diethylphosphono-β-D-allofuranosyl]-5-iodo-uracil

: 1601493-92-8
1-[6-deoxy-6-diethylphosphono-β-D-allofuranosyl]-5-phenylethynyl-uracil

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / methanol / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Darkness

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; triethylamine; In methanol; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.ejmech.2014.02.055

Reference yield:

: 1601493-86-0
1-[3-O-benzoyl-6-deoxy-2,5-O-diacetyl-6-diethylphosphono-β-D-allofuranosyl]-5-iodo-uracil

: 1-[6-deoxy-6-phosphono-β-D-allofuranosyl]-5-phenylethynyl-uracil disodium salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia / methanol / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Darkness

3.1: trimethylsilyl bromide / N,N-dimethyl-formamide / 0 - 20 °C

3.2: pH 7

4.1: Dowex Na⁺ ion exchange column

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl bromide; ammonia; triethylamine; In methanol; N,N-dimethyl-formamide; 2.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.ejmech.2014.02.055