(+)-(S)-1-benzyl-3-(methoxycarbonyl)methyl-4-[3-(methoxycarbonyl)methoxybenzyl]-1,4-benzodiazepine-2,5-dione

Base Information

Chemical Name:(+)-(S)-1-benzyl-3-(methoxycarbonyl)methyl-4-[3-(methoxycarbonyl)methoxybenzyl]-1,4-benzodiazepine-2,5-dione
CAS No.:636600-04-9
Molecular Formula:C₂₉H₂₈N₂O₇
Molecular Weight:516.551
Hs Code.:

Synonyms:(+)-(S)-1-benzyl-3-(methoxycarbonyl)methyl-4-[3-(methoxycarbonyl)methoxybenzyl]-1,4-benzodiazepine-2,5-dione

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Chemical Property of (+)-(S)-1-benzyl-3-(methoxycarbonyl)methyl-4-[3-(methoxycarbonyl)methoxybenzyl]-1,4-benzodiazepine-2,5-dione

Chemical Property:

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Technology Process of (+)-(S)-1-benzyl-3-(methoxycarbonyl)methyl-4-[3-(methoxycarbonyl)methoxybenzyl]-1,4-benzodiazepine-2,5-dione

There total 5 articles about (+)-(S)-1-benzyl-3-(methoxycarbonyl)methyl-4-[3-(methoxycarbonyl)methoxybenzyl]-1,4-benzodiazepine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 880768-89-8
(+)-(S)-4-[3-(methoxycarbonyl)methoxybenzyl]-3-(methoxycarbonyl)methyl-1,4-benzodiazepine-2,5-dione

: 100-39-0
benzyl bromide

: 636600-04-9
(+)-(S)-1-benzyl-3-(methoxycarbonyl)methyl-4-[3-(methoxycarbonyl)methoxybenzyl]-1,4-benzodiazepine-2,5-dione

Guidance literature:: (+)-(S)-4-[3-(methoxycarbonyl)methoxybenzyl]-3-(methoxycarbonyl)methyl-1,4-benzodiazepine-2,5-dione; With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

benzyl bromide; In N,N-dimethyl-formamide; at 25 ℃; for 4h;
DOI:10.1039/b514937a

Reference yield:

: 880768-77-4
(-)-(S)-N-[3-(methoxycarbonyl)methoxybenzyl] aspartic acid dimethyl ester

: 636600-04-9
(+)-(S)-1-benzyl-3-(methoxycarbonyl)methyl-4-[3-(methoxycarbonyl)methoxybenzyl]-1,4-benzodiazepine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94 percent / K₂CO₃; Bu₄NI / CH₂Cl₂ / 4 h / 25 °C

2.1: zinc; NH₄Cl / methanol / 0.17 h / 25 °C

3.1: 1.56 g / p-TsOH monohydrate / methanol / 6 h / Heating

4.1: K₂CO₃ / dimethylformamide / 1 h / 25 °C

4.2: 86 percent / dimethylformamide / 4 h / 25 °C

With tetra-(n-butyl)ammonium iodide; potassium carbonate; ammonium chloride; toluene-4-sulfonic acid; zinc; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b514937a

Reference yield:

: 880768-83-2
(-)-(S)-N-[3-(methoxycarbonyl)methoxybenzyl]-N-(2-nitrobenzoyl) aspartic acid dimethyl ester

: 636600-04-9
(+)-(S)-1-benzyl-3-(methoxycarbonyl)methyl-4-[3-(methoxycarbonyl)methoxybenzyl]-1,4-benzodiazepine-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc; NH₄Cl / methanol / 0.17 h / 25 °C

2.1: 1.56 g / p-TsOH monohydrate / methanol / 6 h / Heating

3.1: K₂CO₃ / dimethylformamide / 1 h / 25 °C

3.2: 86 percent / dimethylformamide / 4 h / 25 °C

With potassium carbonate; ammonium chloride; toluene-4-sulfonic acid; zinc; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/b514937a