2-acetylamino-2-{2-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-ethyl}-malonic acid

Base Information

• Chemical Name: 2-acetylamino-2-{2-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-ethyl}-malonic acid
• CAS No.: 338735-80-1
• Molecular Formula: C₁₅H₁₃F₃N₄O₈
• Molecular Weight: 434.285

Synonyms:2-acetylamino-2-{2-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-ethyl}-malonic acid

Chemical Property of 2-acetylamino-2-{2-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-ethyl}-malonic acid

Chemical Property:

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Technology Process of 2-acetylamino-2-{2-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-ethyl}-malonic acid

There total 3 articles about 2-acetylamino-2-{2-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-ethyl}-malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

diethyl acetamido[2-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitro-1-phenoxy]ethyl]malonate (338735-79-8) → 2-acetylamino-2-{2-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-ethyl}-malonic acid (338735-80-1)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃;

DOI:10.3987/com-00-s(i)90

Reference yield:

2-acetylaminomalonic acid diethyl ester (1068-90-2) → 2-acetylamino-2-{2-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-ethyl}-malonic acid (338735-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / KH / dimethylformamide / 24 h / -42 - 20 °C

2: 84 percent / aq. NaOH / ethanol; H₂O / 20 °C

With sodium hydroxide; potassium hydride; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.3987/com-00-s(i)90

Reference yield:

4-(1-azi-2,2,2-trifluoroethyl)-1-(2-bromoethoxy)-2-nitrobenzene (271252-28-9) → 2-acetylamino-2-{2-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-ethyl}-malonic acid (338735-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / KH / dimethylformamide / 24 h / -42 - 20 °C

2: 84 percent / aq. NaOH / ethanol; H₂O / 20 °C

With sodium hydroxide; potassium hydride; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.3987/com-00-s(i)90

upstream raw materials:

diethyl acetamido[2-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitro-1-phenoxy]ethyl]malonate

2-acetylaminomalonic acid diethyl ester

4-(1-azi-2,2,2-trifluoroethyl)-1-(2-bromoethoxy)-2-nitrobenzene

Downstream raw materials:

L-2-amino-4-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitro-1-phenoxy]butanoic acid

2-tert-butoxycarbonylamino-4-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-butyric acid

2-tert-butoxycarbonylamino-4-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-butyric acid tert-butyl ester

2-[2-(2-tert-butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-4-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-butyric acid tert-butyl ester

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