tert-butyl bis[2-(S)-(2-methoxymethylpyrrolidino)phenyl]phosphine oxide

Base Information

Chemical Name:tert-butyl bis[2-(S)-(2-methoxymethylpyrrolidino)phenyl]phosphine oxide
CAS No.:896462-18-3
Molecular Formula:C₂₈H₄₁N₂O₃P
Molecular Weight:484.619
Hs Code.:

Synonyms:tert-butyl bis[2-(S)-(2-methoxymethylpyrrolidino)phenyl]phosphine oxide

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Chemical Property of tert-butyl bis[2-(S)-(2-methoxymethylpyrrolidino)phenyl]phosphine oxide

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Technology Process of tert-butyl bis[2-(S)-(2-methoxymethylpyrrolidino)phenyl]phosphine oxide

There total 3 articles about tert-butyl bis[2-(S)-(2-methoxymethylpyrrolidino)phenyl]phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 896462-16-1
tert-butyl bis(2-methoxyphenyl)phosphine oxide

: 63126-47-6
(2S)-2-(methoxymethyl)-1-pyrrolidine

: 896462-18-3
tert-butyl bis[2-(S)-(2-methoxymethylpyrrolidino)phenyl]phosphine oxide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/j.tetasy.2006.03.010

Reference yield:

: tert-butyl-bis-(2-methoxy-phenyl)-phosphane

: 896462-18-3
tert-butyl bis[2-(S)-(2-methoxymethylpyrrolidino)phenyl]phosphine oxide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen peroxide / acetone / 1 h

2: 73 percent / n-BuLi / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; dihydrogen peroxide; In tetrahydrofuran; acetone;
DOI:10.1016/j.tetasy.2006.03.010

Reference yield:

: 100-66-3
methoxybenzene

: 896462-18-3
tert-butyl bis[2-(S)-(2-methoxymethylpyrrolidino)phenyl]phosphine oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: TMEDA; n-BuLi / diethyl ether; hexane / 2 h / 20 °C

1.2: diethyl ether; hexane / 0.5 h

2.1: hydrogen peroxide / acetone / 1 h

3.1: 73 percent / n-BuLi / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; dihydrogen peroxide; In tetrahydrofuran; diethyl ether; hexane; acetone;
DOI:10.1016/j.tetasy.2006.03.010