rac-3-(4-benzoyl-piperazin-1-yl)-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one

Base Information

Chemical Name:rac-3-(4-benzoyl-piperazin-1-yl)-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one
CAS No.:1015685-67-2
Molecular Formula:C₂₆H₂₃Cl₂N₃O₂
Molecular Weight:480.394
Hs Code.:

Synonyms:rac-3-(4-benzoyl-piperazin-1-yl)-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one

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Chemical Property of rac-3-(4-benzoyl-piperazin-1-yl)-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one

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Technology Process of rac-3-(4-benzoyl-piperazin-1-yl)-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one

There total 7 articles about rac-3-(4-benzoyl-piperazin-1-yl)-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: rac-6-chloro-3-(3-chloro-benzyl)-3-piperazin-1-yl-1,3-dihydro-indol-2-one

: 98-88-4
benzoyl chloride

: 1015685-67-2
rac-3-(4-benzoyl-piperazin-1-yl)-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

Reference yield:

: 56341-37-8
6-chloro-2-oxindole

: 1015685-67-2
rac-3-(4-benzoyl-piperazin-1-yl)-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: pyrrolidine / methanol / 3 h / 70 °C

2: sodium tetrahydroborate / methanol; dimethyl sulfoxide / 0.5 - 1 h / 20 °C

3: pyridinium hydrobromide perbromide / water; tert-butyl alcohol / 4 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

5: trifluoroacetic acid / 0.5 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With pyrrolidine; sodium tetrahydroborate; pyridinium hydrobromide perbromide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol;

Reference yield:

: rac-4-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-piperazine-1-carboxylic acid tert-butyl ester

: 1015685-67-2
rac-3-(4-benzoyl-piperazin-1-yl)-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 0.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In acetonitrile;