Thiophene-2-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indol-6-ylmethyl)-phenyl]-amide

Base Information

Chemical Name:Thiophene-2-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indol-6-ylmethyl)-phenyl]-amide
CAS No.:920003-00-5
Molecular Formula:C₂₀H₁₆N₂O₂S
Molecular Weight:348.425
Hs Code.:

Synonyms:Thiophene-2-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indol-6-ylmethyl)-phenyl]-amide

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Chemical Property of Thiophene-2-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indol-6-ylmethyl)-phenyl]-amide

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Technology Process of Thiophene-2-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indol-6-ylmethyl)-phenyl]-amide

There total 1 articles about Thiophene-2-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indol-6-ylmethyl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 5271-67-0
2-Thiophenecarbonyl chloride

: 920002-99-9
6-(3-Amino-benzyl)-1,3-dihydro-indol-2-one

: 920003-00-5
Thiophene-2-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indol-6-ylmethyl)-phenyl]-amide

Guidance literature:: 2-Thiophenecarbonyl chloride; 6-(3-Amino-benzyl)-1,3-dihydro-indol-2-one; In tetrahydrofuran; for 2h; Heating / reflux;

With sodium hydroxide; In ethanol; water; for 0.5h;

With hydrogenchloride; In ethanol; water; pH=1;

Reference yield: 53.0%

: 920003-00-5
Thiophene-2-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indol-6-ylmethyl)-phenyl]-amide

: 109-94-4
formic acid ethyl ester

: 920003-01-6
thiophene-2-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indol-6-ylmethyl)-phenyl]-amide

Guidance literature:: Thiophene-2-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indol-6-ylmethyl)-phenyl]-amide; formic acid ethyl ester; With sodium ethanolate; In ethanol; at 78 ℃; for 1h;

With hydrogenchloride; water; In ethanol; at 20 ℃; pH=1;