(S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid tert-butyl ester

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Chemical Name:(S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid tert-butyl ester
CAS No.:207502-35-0
Molecular Formula:C₃₁H₃₅N₃O₅S
Molecular Weight:561.702
Hs Code.:

Synonyms:(S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid tert-butyl ester

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Chemical Property of (S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid tert-butyl ester

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Technology Process of (S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid tert-butyl ester

There total 1 articles about (S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.3%

: 20260-53-1
pyridine-3-carbonyl chloride hydrochloride

: 207502-34-9
(S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid

: 207502-35-0
(S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 25 ℃; for 3h;
DOI:10.1016/S0968-0896(97)10048-7

Reference yield:

: 207502-35-0
(S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid tert-butyl ester

: 207502-34-9
(S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 25 ℃; for 2h;
DOI:10.1016/S0968-0896(97)10048-7

Reference yield:

: 207502-35-0
(S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid tert-butyl ester

: (4S)-4-((2S)-benzyl-3-mercaptopropionylamino)-4-(N-phenylcarbamoyl)-butyric acid t-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.96 g / HCl / ethyl acetate / 2 h / 25 °C

2: Et₃N / CH₂Cl₂ / 3 h / 25 °C

3: 81.2 percent / K₂CO₃ / methanol / 1 h / 25 °C

With hydrogenchloride; potassium carbonate; triethylamine; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0968-0896(97)10048-7