(S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid

Base Information

• Chemical Name: (S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid
• CAS No.: 207502-34-9
• Molecular Formula: C₂₇H₂₇N₃O₅S
• Molecular Weight: 505.594
• Mol file: 207502-34-9.mol

Synonyms:(S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid

Chemical Property of (S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid

There total 1 articles about (S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid tert-butyl ester (207502-35-0) → (S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid (207502-34-9)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 25 ℃; for 2h;

DOI:10.1016/S0968-0896(97)10048-7

Reference yield: 81.3%

pyridine-3-carbonyl chloride hydrochloride (20260-53-1) + (S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid (207502-34-9) → (S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid tert-butyl ester (207502-35-0)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 3h;

DOI:10.1016/S0968-0896(97)10048-7

Reference yield:

benzoyl chloride (98-88-4) + (S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid (207502-34-9) → (S)-4-((S)-2-Benzoylsulfanylmethyl-3-phenyl-propionylamino)-4-phenylcarbamoyl-butyric acid tert-butyl ester (126349-19-7)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 3h;

DOI:10.1016/S0968-0896(97)10048-7

upstream raw materials:

(S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid tert-butyl ester

Downstream raw materials:

(S)-4-Phenylcarbamoyl-4-[(S)-3-phenyl-2-(pyridine-3-carbonylsulfanylmethyl)-propionylamino]-butyric acid tert-butyl ester

(S)-4-((S)-2-Benzoylsulfanylmethyl-3-phenyl-propionylamino)-4-phenylcarbamoyl-butyric acid tert-butyl ester