1,1-dimethylethyl {[4-(3-{[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinyl]sulfonyl}carbamate

Base Information

• Chemical Name: 1,1-dimethylethyl {[4-(3-{[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinyl]sulfonyl}carbamate
• CAS No.: 916810-75-8
• Molecular Formula: C₂₃H₂₆F₆N₆O₅S
• Molecular Weight: 612.553

Synonyms:1,1-dimethylethyl {[4-(3-{[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinyl]sulfonyl}carbamate

Chemical Property of 1,1-dimethylethyl {[4-(3-{[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinyl]sulfonyl}carbamate

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Technology Process of 1,1-dimethylethyl {[4-(3-{[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinyl]sulfonyl}carbamate

There total 1 articles about 1,1-dimethylethyl {[4-(3-{[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinyl]sulfonyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[{[5-(4-piperidinyl)-1,2,4-oxadiazol-3-yl]methyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (916810-74-7) + N-tert-butyloxycarbonylsulfamoyl chloride (147000-89-3) → 1,1-dimethylethyl {[4-(3-{[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinyl]sulfonyl}carbamate (916810-75-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 15h; Cooling with ice;

Reference yield: 48.0%

1,1-dimethylethyl {[4-(3-{[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinyl]sulfonyl}carbamate (916810-75-8) → 4-(3-{[[4-Cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinesulfonamide (916809-01-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 3h;

upstream raw materials:

4-[{[5-(4-piperidinyl)-1,2,4-oxadiazol-3-yl]methyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

N-tert-butyloxycarbonylsulfamoyl chloride

Downstream raw materials:

4-(3-{[[4-Cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinesulfonamide

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