4-[{[5-(4-piperidinyl)-1,2,4-oxadiazol-3-yl]methyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Base Information

• Chemical Name: 4-[{[5-(4-piperidinyl)-1,2,4-oxadiazol-3-yl]methyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile
• CAS No.: 916810-74-7
• Molecular Formula: C₁₈H₁₇F₆N₅O
• Molecular Weight: 433.356

Synonyms:4-[{[5-(4-piperidinyl)-1,2,4-oxadiazol-3-yl]methyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Chemical Property of 4-[{[5-(4-piperidinyl)-1,2,4-oxadiazol-3-yl]methyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Chemical Property:

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Technology Process of 4-[{[5-(4-piperidinyl)-1,2,4-oxadiazol-3-yl]methyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

There total 1 articles about 4-[{[5-(4-piperidinyl)-1,2,4-oxadiazol-3-yl]methyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl 4-(3-{[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinecarboxylate (916810-73-6) → 4-[{[5-(4-piperidinyl)-1,2,4-oxadiazol-3-yl]methyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (916810-74-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 93.0%

trimethylsilyl isocyanate (1118-02-1) + 4-[{[5-(4-piperidinyl)-1,2,4-oxadiazol-3-yl]methyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (916810-74-7) → 4-(3-{[[4-Cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinecarboxamide (916809-33-1)

Guidance literature:

In dichloromethane; at 20 ℃;

Reference yield: 77.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-[{[5-(4-piperidinyl)-1,2,4-oxadiazol-3-yl]methyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (916810-74-7) → 4-[{[5-(1-Methyl-4-piperidinyl)-1,2,4-oxadiazol-3-yl]methyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (916809-36-4)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; water; at 20 ℃; for 15h;

upstream raw materials:

1,1-dimethylethyl 4-(3-{[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinecarboxylate

Downstream raw materials:

4-(3-{[[4-Cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinecarboxamide

1,1-dimethylethyl {[4-(3-{[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-1-piperidinyl]sulfonyl}carbamate

4-[{[5-(1-Methyl-4-piperidinyl)-1,2,4-oxadiazol-3-yl]methyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

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