5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)-2-[(2,6-difluorophenyl)methoxy]pyrimidine

Base Information

Chemical Name:5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)-2-[(2,6-difluorophenyl)methoxy]pyrimidine
CAS No.:1415640-20-8
Molecular Formula:C₁₉H₁₂F₄N₂O₃
Molecular Weight:392.309
Hs Code.:

Synonyms:5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)-2-[(2,6-difluorophenyl)methoxy]pyrimidine

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Chemical Property of 5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)-2-[(2,6-difluorophenyl)methoxy]pyrimidine

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Technology Process of 5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)-2-[(2,6-difluorophenyl)methoxy]pyrimidine

There total 2 articles about 5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)-2-[(2,6-difluorophenyl)methoxy]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1345119-65-4
2-(2,2-difluoro-6-methylbenzo[d][1,3]dioxol-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1415640-19-5
2-[(2,6-difluorophenyl)methoxy]-5-bromopyrimidine

: 1415640-20-8
5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)-2-[(2,6-difluorophenyl)methoxy]pyrimidine

Guidance literature:: With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; acetonitrile; at 85 ℃; for 3h; Inert atmosphere;

Reference yield:

: 19064-18-7
2,6-difluorobenzyl alcohol

: 1415640-20-8
5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)-2-[(2,6-difluorophenyl)methoxy]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: potassium phosphate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / 1,4-dioxane; acetonitrile; water / 3 h / 85 °C / Inert atmosphere

With potassium phosphate; sodium hydride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; mineral oil;