ethyl (3S)-3-[dimethyl(phenyl)silyl]-2-(ethoxycarbonyl)-5-oxohexadecanoate

Base Information

Chemical Name:ethyl (3S)-3-[dimethyl(phenyl)silyl]-2-(ethoxycarbonyl)-5-oxohexadecanoate
CAS No.:1326703-72-3
Molecular Formula:C₂₉H₄₈O₅Si
Molecular Weight:504.783
Hs Code.:

Synonyms:ethyl (3S)-3-[dimethyl(phenyl)silyl]-2-(ethoxycarbonyl)-5-oxohexadecanoate

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Chemical Property of ethyl (3S)-3-[dimethyl(phenyl)silyl]-2-(ethoxycarbonyl)-5-oxohexadecanoate

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Technology Process of ethyl (3S)-3-[dimethyl(phenyl)silyl]-2-(ethoxycarbonyl)-5-oxohexadecanoate

There total 1 articles about ethyl (3S)-3-[dimethyl(phenyl)silyl]-2-(ethoxycarbonyl)-5-oxohexadecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 593-08-8
tridecan-2-one

: 130247-53-9
ethyl 2-ethoxycarbonyl-3-dimethyl(phenyl)silyl-2-propenoate

: ethyl (3R)-3-[dimethyl(phenyl)silyl]-2-(ethoxycarbonyl)-5-oxohexadecanoate

: 1326703-72-3
ethyl (3S)-3-[dimethyl(phenyl)silyl]-2-(ethoxycarbonyl)-5-oxohexadecanoate

Guidance literature:: With (S)-2-(1-pyrrolidinylmethyl)pyrrolidine; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; at 4 ℃; for 144h; optical yield given as %ee; enantioselective reaction;
DOI:10.1055/s-0030-1260036

Reference yield: 80.0%

: 1326703-72-3
ethyl (3S)-3-[dimethyl(phenyl)silyl]-2-(ethoxycarbonyl)-5-oxohexadecanoate

: 1326703-75-6
ethyl (3S)-3-[dimethyl(phenyl)silyl]-5-oxohexadecanoate

Guidance literature:: With water; sodium chloride; In dimethyl sulfoxide; at 165 - 180 ℃; for 6h; Inert atmosphere;
DOI:10.1055/s-0030-1260036

Reference yield:

: 1326703-72-3
ethyl (3S)-3-[dimethyl(phenyl)silyl]-2-(ethoxycarbonyl)-5-oxohexadecanoate

: C₂₆H₄₆O₃Si

: C₂₆H₄₆O₃Si

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium chloride / dimethyl sulfoxide / 6 h / 165 - 180 °C / Inert atmosphere

2: sodium tetrahydroborate / ethanol / 5 h / 0 °C

With sodium tetrahydroborate; water; sodium chloride; In ethanol; dimethyl sulfoxide; 1: Krapcho de-ethoxycarbonylation;
DOI:10.1055/s-0030-1260036