N(α)-benzyloxycarbonyl-N(?)-(2-trimethylsilylethoxy)methyl-L-histidine methyl ester

Base Information

• Chemical Name: N(α)-benzyloxycarbonyl-N(?)-(2-trimethylsilylethoxy)methyl-L-histidine methyl ester
• CAS No.: 99523-90-7
• Molecular Formula: C₂₁H₃₁N₃O₅Si
• Molecular Weight: 433.58

Synonyms:N(α)-benzyloxycarbonyl-N(?)-(2-trimethylsilylethoxy)methyl-L-histidine methyl ester

Chemical Property of N(α)-benzyloxycarbonyl-N(?)-(2-trimethylsilylethoxy)methyl-L-histidine methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of N(α)-benzyloxycarbonyl-N(?)-(2-trimethylsilylethoxy)methyl-L-histidine methyl ester

There total 1 articles about N(α)-benzyloxycarbonyl-N(?)-(2-trimethylsilylethoxy)methyl-L-histidine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) + N(α)-benzyloxycarbonyl-N(τ)-tert-butyloxycarbonyl-L-histidine methyl ester (90653-42-2) → N(α)-benzyloxycarbonyl-N(?)-(2-trimethylsilylethoxy)methyl-L-histidine methyl ester (99523-90-7)

Guidance literature:

In ethyl acetate; 1.) 0 deg C, 2 h, 2.) room temp., 2 h.;

Reference yield:

N(α)-benzyloxycarbonyl-N(?)-(2-trimethylsilylethoxy)methyl-L-histidine methyl ester (99523-90-7) + methyl iodide (74-88-4) → 3-methyl-L-histidine (368-16-1) + His(1-CH3) (332-80-9,163750-77-4)

Guidance literature:

With hydrogenchloride; Multistep reaction; 1.) (DMF), 24 h, room temp., 2.) reflux, 24 h;

upstream raw materials:

(2-trimethylethylsilylethoxy)methyl chloride

N(α)-benzyloxycarbonyl-N(τ)-tert-butyloxycarbonyl-L-histidine methyl ester

Downstream raw materials:

3-methyl-L-histidine

His(1-CH₃)

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