(E)-2-{2,2,3,3,4,4,4-Heptafluoro-1-[2-oxo-2-thiophen-2-yl-eth-(Z)-ylidene]-butyl}-4-(triphenyl-λ⁵-phosphanylidene)-pent-2-enedioic acid dimethyl ester

Base Information

• Chemical Name: (E)-2-{2,2,3,3,4,4,4-Heptafluoro-1-[2-oxo-2-thiophen-2-yl-eth-(Z)-ylidene]-butyl}-4-(triphenyl-λ⁵-phosphanylidene)-pent-2-enedioic acid dimethyl ester
• CAS No.: 193197-08-9
• Molecular Formula: C₃₅H₂₆F₇O₅PS
• Molecular Weight: 722.617
• Mol file: 193197-08-9.mol

Synonyms:(E)-2-{2,2,3,3,4,4,4-Heptafluoro-1-[2-oxo-2-thiophen-2-yl-eth-(Z)-ylidene]-butyl}-4-(triphenyl-λ⁵-phosphanylidene)-pent-2-enedioic acid dimethyl ester

Chemical Property of (E)-2-{2,2,3,3,4,4,4-Heptafluoro-1-[2-oxo-2-thiophen-2-yl-eth-(Z)-ylidene]-butyl}-4-(triphenyl-λ⁵-phosphanylidene)-pent-2-enedioic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-{2,2,3,3,4,4,4-Heptafluoro-1-[2-oxo-2-thiophen-2-yl-eth-(Z)-ylidene]-butyl}-4-(triphenyl-λ⁵-phosphanylidene)-pent-2-enedioic acid dimethyl ester

There total 2 articles about (E)-2-{2,2,3,3,4,4,4-Heptafluoro-1-[2-oxo-2-thiophen-2-yl-eth-(Z)-ylidene]-butyl}-4-(triphenyl-λ⁵-phosphanylidene)-pent-2-enedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

methyl 4,4,5,5,6,6,6-heptafluorohex-2-ynoate (70577-96-7) + (E)-5-Oxo-5-thiophen-2-yl-2-(triphenyl-λ5-phosphanylidene)-pent-3-enoic acid methyl ester (193196-98-4) → (2Z,4E)-3-Heptafluoropropyl-4-(thiophene-2-carbonyl)-6-(triphenyl-λ5-phosphanylidene)-hepta-2,4-dienedioic acid dimethyl ester + (E)-2-{2,2,3,3,4,4,4-Heptafluoro-1-[2-oxo-2-thiophen-2-yl-eth-(Z)-ylidene]-butyl}-4-(triphenyl-λ5-phosphanylidene)-pent-2-enedioic acid dimethyl ester (193197-08-9)

Guidance literature:

In dichloromethane; at 25 ℃; for 30h;

DOI:10.1016/S0022-1139(96)03561-0

Reference yield:

(α-Thienacyl)methyltriphenylphosphonium bromide (15109-98-5) → (E)-2-{2,2,3,3,4,4,4-Heptafluoro-1-[2-oxo-2-thiophen-2-yl-eth-(Z)-ylidene]-butyl}-4-(triphenyl-λ5-phosphanylidene)-pent-2-enedioic acid dimethyl ester (193197-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / K₂CO₃ / CH₂Cl₂ / 3 h / 90 °C

2: 32 percent / CH₂Cl₂ / 30 h / 25 °C

With potassium carbonate; In dichloromethane;

DOI:10.1016/S0022-1139(96)03561-0

Reference yield: 90.0%

(E)-2-{2,2,3,3,4,4,4-Heptafluoro-1-[2-oxo-2-thiophen-2-yl-eth-(Z)-ylidene]-butyl}-4-(triphenyl-λ5-phosphanylidene)-pent-2-enedioic acid dimethyl ester (193197-08-9) → 4-Heptafluoropropyl-6-thiophen-2-yl-isophthalic acid dimethyl ester

Guidance literature:

In xylene; at 150 ℃; for 3h;

DOI:10.1016/S0022-1139(96)03561-0

upstream raw materials:

methyl 4,4,5,5,6,6,6-heptafluorohex-2-ynoate

(E)-5-Oxo-5-thiophen-2-yl-2-(triphenyl-λ⁵-phosphanylidene)-pent-3-enoic acid methyl ester

(α-Thienacyl)methyltriphenylphosphonium bromide