(2R,3R)-2-Benzyl-5-[(S)-2-((S)-2-benzyloxycarbonylamino-propionylamino)-propionylamino]-3-hydroxy-pentanoic acid methyl ester

Base Information

Chemical Name:(2R,3R)-2-Benzyl-5-[(S)-2-((S)-2-benzyloxycarbonylamino-propionylamino)-propionylamino]-3-hydroxy-pentanoic acid methyl ester
CAS No.:219992-23-1
Molecular Formula:C₂₇H₃₅N₃O₇
Molecular Weight:513.591
Hs Code.:

Synonyms:(2R,3R)-2-Benzyl-5-[(S)-2-((S)-2-benzyloxycarbonylamino-propionylamino)-propionylamino]-3-hydroxy-pentanoic acid methyl ester

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Chemical Property of (2R,3R)-2-Benzyl-5-[(S)-2-((S)-2-benzyloxycarbonylamino-propionylamino)-propionylamino]-3-hydroxy-pentanoic acid methyl ester

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Technology Process of (2R,3R)-2-Benzyl-5-[(S)-2-((S)-2-benzyloxycarbonylamino-propionylamino)-propionylamino]-3-hydroxy-pentanoic acid methyl ester

There total 8 articles about (2R,3R)-2-Benzyl-5-[(S)-2-((S)-2-benzyloxycarbonylamino-propionylamino)-propionylamino]-3-hydroxy-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 617-55-0
dimethyl (S)-malate

: 219992-23-1
(2R,3R)-2-Benzyl-5-[(S)-2-((S)-2-benzyloxycarbonylamino-propionylamino)-propionylamino]-3-hydroxy-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, from -78 deg C to -50 deg C, 6 h

2: 1.) BH₃*DMS, 2.) NaBH₄ / 1.) THF, 0 deg C, 1 h, 2.) THF, RT, 30 min

3: pyridine / CH₂Cl₂ / 12 h / 0 °C

4: K₂CO₃ / methanol / 1 h / 0 °C

5: 85 percent / acetonitrile / Ambient temperature

6: 100 percent / H₂, HCl / 10percent Pd/C / methanol / 2 h / 2068.6 Torr / Ambient temperature

7: 1.) 1-hydroxybenzotriazole, dicyclohexylcarbodiimide, 2.) Et₃N / 1.) CH₂Cl₂, 1 h, 2.) CH₂Cl₂, RT, 24 h

With pyridine; hydrogenchloride; sodium tetrahydroborate; dimethylsulfide borane complex; hydrogen; potassium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/ja983063e

Reference yield:

: 100-39-0
benzyl bromide

: 219992-23-1
(2R,3R)-2-Benzyl-5-[(S)-2-((S)-2-benzyloxycarbonylamino-propionylamino)-propionylamino]-3-hydroxy-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, from -78 deg C to -50 deg C, 6 h

2: 1.) BH₃*DMS, 2.) NaBH₄ / 1.) THF, 0 deg C, 1 h, 2.) THF, RT, 30 min

3: pyridine / CH₂Cl₂ / 12 h / 0 °C

4: K₂CO₃ / methanol / 1 h / 0 °C

5: 85 percent / acetonitrile / Ambient temperature

6: 100 percent / H₂, HCl / 10percent Pd/C / methanol / 2 h / 2068.6 Torr / Ambient temperature

7: 1.) 1-hydroxybenzotriazole, dicyclohexylcarbodiimide, 2.) Et₃N / 1.) CH₂Cl₂, 1 h, 2.) CH₂Cl₂, RT, 24 h

With pyridine; hydrogenchloride; sodium tetrahydroborate; dimethylsulfide borane complex; hydrogen; potassium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/ja983063e

Reference yield:

: 201669-76-3
(R)-2-(S)-Oxiranyl-3-phenyl-propionic acid methyl ester

: 219992-23-1
(2R,3R)-2-Benzyl-5-[(S)-2-((S)-2-benzyloxycarbonylamino-propionylamino)-propionylamino]-3-hydroxy-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / acetonitrile / Ambient temperature

2: 100 percent / H₂, HCl / 10percent Pd/C / methanol / 2 h / 2068.6 Torr / Ambient temperature

3: 1.) 1-hydroxybenzotriazole, dicyclohexylcarbodiimide, 2.) Et₃N / 1.) CH₂Cl₂, 1 h, 2.) CH₂Cl₂, RT, 24 h

With hydrogenchloride; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1021/ja983063e