N-[2-{2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid tert-butyl ester

Base Information

Chemical Name:N-[2-{2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid tert-butyl ester
CAS No.:835916-20-6
Molecular Formula:C₅₇H₆₂Cl₂N₆O₉
Molecular Weight:1046.06
Hs Code.:

<i>N</i>-[2-{2-[2-<i>tert</i>-butoxycarbonylamino-3-(1<i>H</i>-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-succinamic acid <i>tert</i>-butyl ester

Synonyms:N-[2-{2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid tert-butyl ester

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Chemical Property of N-[2-{2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid tert-butyl ester

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Technology Process of N-[2-{2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid tert-butyl ester

There total 7 articles about N-[2-{2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71989-14-5,112883-39-3
N-(9-fluorenylmethoxycarbonyl)-4-O-tert-butyl-D-aspartic acid

: 835915-25-8
[1-(S)-{1-(S)-[2-amino-1-(R)-(3,4-dichlorobenzyl)ethylcarbamoyl]-2-phenylethylcarbamoyl}-2-(1H-indol-3-yl)ethyl]carbamic acid tert-butyl ester

: 835916-20-6
N-[2-{2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid tert-butyl ester

Guidance literature:: N-(9-fluorenylmethoxycarbonyl)-4-O-tert-butyl-D-aspartic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 30h;

[1-(S)-{1-(S)-[2-amino-1-(R)-(3,4-dichlorobenzyl)ethylcarbamoyl]-2-phenylethylcarbamoyl}-2-(1H-indol-3-yl)ethyl]carbamic acid tert-butyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm040832y

Reference yield:

: [1-aminomethyl-2-(3,4-dichloro-phenyl)-ethyl]-carbamic acid tert-butyl ester

: 835916-20-6
N-[2-{2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: Et₃N / tetrahydrofuran / 1 h / 20 °C

2.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

3.1: HOBt; EDC*HCl / dimethylformamide / 0.5 h / 0 °C

3.2: 1.13 g / Et₃N / dimethylformamide / 4 h / 20 °C

4.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

5.1: HOBt; EDC*HCl; DIPEA / dimethylformamide / 2 h / 20 °C

6.1: Et₂NH / dimethylformamide / 2 h

7.1: HOBt; EDC*HCl / dimethylformamide / 30 h

7.2: dimethylformamide / 2 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm040832y

Reference yield:

: 835916-14-8
[2-amino-3-(3,4-dichloro-phenyl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

: 835916-20-6
N-[2-{2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: HOBt; EDC*HCl / dimethylformamide / 0.5 h / 0 °C

1.2: 1.13 g / Et₃N / dimethylformamide / 4 h / 20 °C

2.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

3.1: HOBt; EDC*HCl; DIPEA / dimethylformamide / 2 h / 20 °C

4.1: Et₂NH / dimethylformamide / 2 h

5.1: HOBt; EDC*HCl / dimethylformamide / 30 h

5.2: dimethylformamide / 2 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm040832y