2-benzyloxycarbonylamino-1-hydroxy-1-[5-(methoxycarbonyl)benzoxazol-2-yl]-3-phenylpropane

Base Information

• Chemical Name: 2-benzyloxycarbonylamino-1-hydroxy-1-[5-(methoxycarbonyl)benzoxazol-2-yl]-3-phenylpropane
• CAS No.: 207235-69-6
• Molecular Formula: C₂₆H₂₄N₂O₆
• Molecular Weight: 460.486

Synonyms:2-benzyloxycarbonylamino-1-hydroxy-1-[5-(methoxycarbonyl)benzoxazol-2-yl]-3-phenylpropane

Chemical Property of 2-benzyloxycarbonylamino-1-hydroxy-1-[5-(methoxycarbonyl)benzoxazol-2-yl]-3-phenylpropane

Chemical Property:

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Technology Process of 2-benzyloxycarbonylamino-1-hydroxy-1-[5-(methoxycarbonyl)benzoxazol-2-yl]-3-phenylpropane

There total 4 articles about 2-benzyloxycarbonylamino-1-hydroxy-1-[5-(methoxycarbonyl)benzoxazol-2-yl]-3-phenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ 2-benzyloxycarbonylamino-1-hydroxy-1-[5-(methoxycarbonyl)benzoxazol-2-yl]-3-phenylpropane (207235-69-6)

Guidance literature:

Reference yield:

N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde (59830-60-3,63219-70-5,68474-26-0) → 2-benzyloxycarbonylamino-1-hydroxy-1-[5-(methoxycarbonyl)benzoxazol-2-yl]-3-phenylpropane (207235-69-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

2: HCl / CHCl₃ / 3 h / 0 °C

3: ethanol / 6 h / Heating

With hydrogenchloride; triethylamine; In ethanol; dichloromethane; chloroform;

DOI:10.1021/jm000496v

Reference yield:

3-(benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutanenitrile (66413-45-4) → 2-benzyloxycarbonylamino-1-hydroxy-1-[5-(methoxycarbonyl)benzoxazol-2-yl]-3-phenylpropane (207235-69-6)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / CHCl₃ / 3 h / 0 °C

2: ethanol / 6 h / Heating

With hydrogenchloride; In ethanol; chloroform;

DOI:10.1021/jm000496v

upstream raw materials:

methyl 3-amino-4-hydroxybenzoate

N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde

3-(benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutanenitrile

Downstream raw materials:

[1-{[1-benzyl-2-(5-diethylcarbamoyl-benzooxazol-2-yl)-2-oxo-ethylcarbamoyl]-methyl}-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester

2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[[5-(ethylaminocarbonyl)benzoxazol-2-yl]hydroxymethyl]-2-phenylethyl]acetamide

2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[[5-(ethylaminocarbonyl)benzoxazol-2-yl]carbonyl]-2-phenylethyl]acetamide

2-(2-{2-[5-benzyloxycarbonylamino-2-(3-nitro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester

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