3-(4-methoxyphenyl)propyl 2,4,6-triisopropylbenzoate

Base Information

• Chemical Name: 3-(4-methoxyphenyl)propyl 2,4,6-triisopropylbenzoate
• CAS No.: 1338073-32-7
• Molecular Formula: C₂₆H₃₆O₃
• Molecular Weight: 396.57
• Mol file: 1338073-32-7.mol

Synonyms:3-(4-methoxyphenyl)propyl 2,4,6-triisopropylbenzoate

Chemical Property of 3-(4-methoxyphenyl)propyl 2,4,6-triisopropylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(4-methoxyphenyl)propyl 2,4,6-triisopropylbenzoate

There total 2 articles about 3-(4-methoxyphenyl)propyl 2,4,6-triisopropylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-(p-methoxyphenyl)-1-propanol (5406-18-8) + 2,4,6-triisopropylbenzoic acid (49623-71-4) → 3-(4-methoxyphenyl)propyl 2,4,6-triisopropylbenzoate (1338073-32-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.202000599

Reference yield: 85.0%

3-(p-methoxyphenyl)-1-propanol (5406-18-8) + 2,4,6-triisopropylbenzoyl chloride (57199-00-5) → 3-(4-methoxyphenyl)propyl 2,4,6-triisopropylbenzoate (1338073-32-7)

Guidance literature:

3-(p-methoxyphenyl)-1-propanol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 3h;

2,4,6-triisopropylbenzoyl chloride; In tetrahydrofuran; mineral oil; at 90 ℃; for 18h; Sealed flask;

DOI:10.1021/ja2077813

Reference yield: 94.0%

3-(4-methoxyphenyl)propyl 2,4,6-triisopropylbenzoate (1338073-32-7) + 2,4,4,5,5-pentamethyl-[1,3,2]dioxaborolane (94242-85-0) → (R)-2-(4-(4-methoxyphenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:

With sec.-butyllithium; sparteine; In diethyl ether; at -78 ℃; for 16h; Heating;

DOI:10.1002/anie.201711816

upstream raw materials:

3-(p-methoxyphenyl)-1-propanol

2,4,6-triisopropylbenzoyl chloride

2,4,6-triisopropylbenzoic acid

Downstream raw materials:

(R)-1-(3-chlorobutyl)-4-methoxybenzene

(S)-4-(4′-methoxyphenyl)-2-butanol

(S)-2-(4-(4-methoxyphenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-(p-methoxyphenyl)but-1-ene

Refernces

• 1、 Linne, Yannick,Sch?nwald, Axel,Wei?bach, Sebastian,Kalesse, Markus. "Desymmetrization of C2-Symmetric Bis(Boronic Esters) by Zweifel Olefinations". supporting information. p. 7998 - 8002. Retrieved 2020/06/09.