2-(4-(4-methoxyphenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(4-(4-methoxyphenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 1338073-35-0
• Molecular Formula: C₁₇H₂₇BO₃
• Molecular Weight: 290.211
• Mol file: 1338073-35-0.mol

Synonyms:2-(4-(4-methoxyphenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of 2-(4-(4-methoxyphenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(4-(4-methoxyphenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 13 articles about 2-(4-(4-methoxyphenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(rac)-4-(3-bromobutyl)-1-methoxybenzene (344791-87-3) + bis(pinacol)diborane (73183-34-3) → 2-(4-(4-methoxyphenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1338073-35-0)

Guidance literature:

With iron(III)-acetylacetonate; N,N,N,N,-tetramethylethylenediamine; ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 12h; Reagent/catalyst; Solvent; Inert atmosphere;

DOI:10.1021/ja505199u

Reference yield: 88.0%

3-(4-methoxyphenyl)propyl 2,4,6-triisopropylbenzoate (1338073-32-7) + 2,4,4,5,5-pentamethyl-[1,3,2]dioxaborolane (94242-85-0) → (S)-2-(4-(4-methoxyphenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1338073-35-0)

Guidance literature:

With sec.-butyllithium; (-)-sparteine; In diethyl ether; at -78 ℃; for 16h; Heating;

DOI:10.1002/anie.201711816

Reference yield: 88.0%

1-(3-chlorobutyl)-4-methoxybenzene + bis(pinacol)diborane (73183-34-3) → 2-(4-(4-methoxyphenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1338073-35-0)

Guidance literature:

With manganese(II) bromide; N,N,N,N,-tetramethylethylenediamine; ethylmagnesium bromide; In 1,2-dimethoxyethane; at 20 ℃; for 4h; Reagent/catalyst; Time; Solvent; Inert atmosphere;

DOI:10.1021/jacs.6b03157

upstream raw materials:

3-(4-methoxyphenyl)propyl 2,4,6-triisopropylbenzoate

2,4,4,5,5-pentamethyl-[1,3,2]dioxaborolane

3-(p-methoxyphenyl)-1-propanol

ethyl 2,4,6-tri-isopropylbenzoate

Downstream raw materials:

(R)-1-(3-chlorobutyl)-4-methoxybenzene

(S)-4-(4′-methoxyphenyl)-2-butanol