2,4-dimethoxybenzyl 3-(diphenylphosphatoxy)-2,2-dimethyl-3-(4-chlorophenyl)propanoate

Base Information

Chemical Name:2,4-dimethoxybenzyl 3-(diphenylphosphatoxy)-2,2-dimethyl-3-(4-chlorophenyl)propanoate
CAS No.:258876-02-7
Molecular Formula:C₃₂H₃₂ClO₈P
Molecular Weight:611.028
Hs Code.:

Synonyms:2,4-dimethoxybenzyl 3-(diphenylphosphatoxy)-2,2-dimethyl-3-(4-chlorophenyl)propanoate

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Chemical Property of 2,4-dimethoxybenzyl 3-(diphenylphosphatoxy)-2,2-dimethyl-3-(4-chlorophenyl)propanoate

Chemical Property:

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Technology Process of 2,4-dimethoxybenzyl 3-(diphenylphosphatoxy)-2,2-dimethyl-3-(4-chlorophenyl)propanoate

There total 1 articles about 2,4-dimethoxybenzyl 3-(diphenylphosphatoxy)-2,2-dimethyl-3-(4-chlorophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 221675-75-8
2,4-dimethoxybenzyl 2-methylpropanoate

: 258876-02-7
2,4-dimethoxybenzyl 3-(diphenylphosphatoxy)-2,2-dimethyl-3-(4-chlorophenyl)propanoate

Guidance literature:: 4-chlorobenzaldehyde; 2,4-dimethoxybenzyl 2-methylpropanoate; With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

chlorophosphoric acid diphenyl ester; In tetrahydrofuran; at -78 - -20 ℃; Further stages.;
DOI:10.1021/jo991570o

Reference yield:

: 258876-02-7
2,4-dimethoxybenzyl 3-(diphenylphosphatoxy)-2,2-dimethyl-3-(4-chlorophenyl)propanoate

: 258876-03-8
3-(diphenylphosphatoxy)-2,2-dimethyl-3-(4-chlorophenyl)propanoic acid

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/jo991570o

Reference yield:

: 258876-02-7
2,4-dimethoxybenzyl 3-(diphenylphosphatoxy)-2,2-dimethyl-3-(4-chlorophenyl)propanoate

: trans-2,2,4-trimethyl-3-(4-chlorophenyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 3 steps

1: CAN / acetonitrile; H₂O / 1 h / 20 °C

2: n-Bu₃P / CH₂Cl₂ / 3 h / 20 °C

3: t-BuSH / 1 h / 20 °C / Photolysis

With ammonium cerium(IV) nitrate; tributylphosphine; 2-methylpropan-2-thiol; In dichloromethane; water; acetonitrile; 1: oxidative cleavage / 2: Esterification / 3: Cyclization;
DOI:10.1021/jo991570o