<2R,3S>-N-methoxy-N,2-dimethyl-5-<(4-methoxyphenyl)methoxy>-3-<(triethylsilyl)oxy>pentanamide

Base Information

• Chemical Name: <2R,3S>-N-methoxy-N,2-dimethyl-5-<(4-methoxyphenyl)methoxy>-3-<(triethylsilyl)oxy>pentanamide
• CAS No.: 129985-92-8
• Molecular Formula: C₂₂H₃₉NO₅Si
• Molecular Weight: 425.641

Synonyms:<2R,3S>-N-methoxy-N,2-dimethyl-5-<(4-methoxyphenyl)methoxy>-3-<(triethylsilyl)oxy>pentanamide

Chemical Property of <2R,3S>-N-methoxy-N,2-dimethyl-5-<(4-methoxyphenyl)methoxy>-3-<(triethylsilyl)oxy>pentanamide

Chemical Property:

Purity/Quality:

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Technology Process of <2R,3S>-N-methoxy-N,2-dimethyl-5-<(4-methoxyphenyl)methoxy>-3-<(triethylsilyl)oxy>pentanamide

There total 3 articles about <2R,3S>-N-methoxy-N,2-dimethyl-5-<(4-methoxyphenyl)methoxy>-3-<(triethylsilyl)oxy>pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(p-methoxybenzyloxy)propanal (128461-65-4) → <2R,3S>-N-methoxy-N,2-dimethyl-5-<(4-methoxyphenyl)methoxy>-3-<(triethylsilyl)oxy>pentanamide (129985-92-8)

Guidance literature:

Multi-step reaction with 3 steps

2: 1.) Me₃Al / 1.) THF, toluene, RT, 30 min, 2.) from -10 to 0 deg C, 2.5 h

3: imidazole / dimethylformamide / 0.5 h

With 1H-imidazole; trimethylaluminum; In N,N-dimethyl-formamide;

DOI:10.1021/ja00175a038

Reference yield:

<3(2R,3S),4R,5S>-3-<3-hydroxy-5-<(4-methoxyphenyl)methoxy>-2-methyl-1-oxopentyl>-4-methyl-5-phenyl-2-oxazolidinone (129985-91-7) → <2R,3S>-N-methoxy-N,2-dimethyl-5-<(4-methoxyphenyl)methoxy>-3-<(triethylsilyl)oxy>pentanamide (129985-92-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Me₃Al / 1.) THF, toluene, RT, 30 min, 2.) from -10 to 0 deg C, 2.5 h

2: imidazole / dimethylformamide / 0.5 h

With 1H-imidazole; trimethylaluminum; In N,N-dimethyl-formamide;

DOI:10.1021/ja00175a038

Reference yield:

triethylsilyl chloride (994-30-9) + (2R,3S)-3-hydroxy-N-methoxy-5-(4-methoxybenzyloxy)-N,2-dimethylpentanamide (152330-77-3) → <2R,3S>-N-methoxy-N,2-dimethyl-5-<(4-methoxyphenyl)methoxy>-3-<(triethylsilyl)oxy>pentanamide (129985-92-8)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 0.5h; Yield given;

DOI:10.1021/ja00175a038

upstream raw materials:

triethylsilyl chloride

(2R,3S)-3-hydroxy-N-methoxy-5-(4-methoxybenzyloxy)-N,2-dimethylpentanamide

3-(p-methoxybenzyloxy)propanal

<3(2R,3S),4R,5S>-3-<3-hydroxy-5-<(4-methoxyphenyl)methoxy>-2-methyl-1-oxopentyl>-4-methyl-5-phenyl-2-oxazolidinone

Downstream raw materials:

<3S,4R,6Z,10S,10(4R,6S)>-10-(2,2-dimethyl-4-ethyl-1,3-dioxan-6-yl)-7-(2,2-dimethylhydrazino)-1-<(4-methoxyphenyl)methoxy>-4-methyl-3-(trimethylsiloxy)-6-undecen-5-one

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