methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propan-1-al

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Chemical Name:methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propan-1-al
CAS No.:158568-67-3
Molecular Formula:C₂₆H₃₂F₃NO₄Si
Molecular Weight:507.625
Hs Code.:

Synonyms:methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propan-1-al

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Chemical Property of methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propan-1-al

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Technology Process of methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propan-1-al

There total 8 articles about methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propan-1-al which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 158469-84-2
methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propionate

: 158568-67-3
methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propan-1-al

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 3.5h;
DOI:10.1016/S0040-4020(01)85516-2

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 158568-67-3
methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propan-1-al

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 5 h / 80 °C

2: benzene / 0.5 h / Ambient temperature

3: NaBH₄ / methanol / 0 deg C, 0.2 h, then 0 deg C --> room temp., 0.5 h

4: 71 percent / sat. sodium bicarbonate / ethyl acetate; H₂O / 1 h / 0 °C

5: 83 percent / diisobutylaluminium hydride / toluene / 3.5 h / -78 °C

With sodium tetrahydroborate; diisobutylaluminium hydride; sodium hydrogencarbonate; In methanol; water; ethyl acetate; toluene; benzene;
DOI:10.1016/S0040-4020(01)85516-2

Reference yield:

: 349-95-1
4-(trifluoromethyl)benzylic alcohol

: 158568-67-3
methyl (2S)-2-<(phenoxycarbonyl)<3-(4-trifluoromethylphenyl)prop-2-en-1-yl>amino>-3-<(tert-butyldimethylsilyl)oxy>propan-1-al

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / pyridinium chlorochromate / CH₂Cl₂ / 2.5 h / Ambient temperature

2: toluene / 5 h / 80 °C

3: benzene / 0.5 h / Ambient temperature

4: NaBH₄ / methanol / 0 deg C, 0.2 h, then 0 deg C --> room temp., 0.5 h

5: 71 percent / sat. sodium bicarbonate / ethyl acetate; H₂O / 1 h / 0 °C

6: 83 percent / diisobutylaluminium hydride / toluene / 3.5 h / -78 °C

With sodium tetrahydroborate; diisobutylaluminium hydride; sodium hydrogencarbonate; pyridinium chlorochromate; In methanol; dichloromethane; water; ethyl acetate; toluene; benzene;
DOI:10.1016/S0040-4020(01)85516-2