4-amino-1-methyl-1H-pyrrole-2-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-phenyl}-amide

Base Information

• Chemical Name: 4-amino-1-methyl-1H-pyrrole-2-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-phenyl}-amide
• CAS No.: 524734-95-0
• Molecular Formula: C₁₆H₂₀Cl₂N₄O
• Molecular Weight: 355.267

Synonyms:4-amino-1-methyl-1H-pyrrole-2-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-phenyl}-amide

Chemical Property of 4-amino-1-methyl-1H-pyrrole-2-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-phenyl}-amide

Chemical Property:

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Technology Process of 4-amino-1-methyl-1H-pyrrole-2-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-phenyl}-amide

There total 5 articles about 4-amino-1-methyl-1H-pyrrole-2-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-4-nitro-1H-pyrrole-2-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-phenyl}-amide (524734-94-9) → 4-amino-1-methyl-1H-pyrrole-2-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-phenyl}-amide (524734-95-0)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1016/S0960-894X(02)00986-1

Reference yield:

1-methyl-4-nitro-pyrrol-2-carboxylic acid (13138-78-8) → 4-amino-1-methyl-1H-pyrrole-2-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-phenyl}-amide (524734-95-0)

Guidance literature:

Multi-step reaction with 4 steps

1: EDCI

2: Et₃N

3: LiCl

4: 100 percent / H₂ / Pd/C

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium chloride; palladium on activated charcoal;

DOI:10.1016/S0960-894X(02)00986-1

Reference yield:

1-methyl-4-nitro-1H-pyrrole-2-carboxylic acid {4-[bis-(2-hydroxy-ethyl)-amino]-phenyl}-amide (524734-89-2) → 4-amino-1-methyl-1H-pyrrole-2-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-phenyl}-amide (524734-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N

2: LiCl

3: 100 percent / H₂ / Pd/C

With hydrogen; triethylamine; lithium chloride; palladium on activated charcoal;

DOI:10.1016/S0960-894X(02)00986-1

upstream raw materials:

1-methyl-4-nitro-1H-pyrrole-2-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-phenyl}-amide

1-methyl-4-nitro-pyrrol-2-carboxylic acid

N,N-bis(2-hydroxyethyl)-4-aminoaniline

1-methyl-4-nitro-1H-pyrrole-2-carboxylic acid {4-[bis-(2-hydroxy-ethyl)-amino]-phenyl}-amide

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