cyclohexyl-(4-difluoromethyl-6-piperazin-1-yl[2,4']bipyridinyl-2'-yl)amine

Base Information

Chemical Name:cyclohexyl-(4-difluoromethyl-6-piperazin-1-yl[2,4']bipyridinyl-2'-yl)amine
CAS No.:1201673-57-5
Molecular Formula:C₂₁H₂₇F₂N₅
Molecular Weight:387.476
Hs Code.:

Synonyms:cyclohexyl-(4-difluoromethyl-6-piperazin-1-yl[2,4']bipyridinyl-2'-yl)amine

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Chemical Property of cyclohexyl-(4-difluoromethyl-6-piperazin-1-yl[2,4']bipyridinyl-2'-yl)amine

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Technology Process of cyclohexyl-(4-difluoromethyl-6-piperazin-1-yl[2,4']bipyridinyl-2'-yl)amine

There total 7 articles about cyclohexyl-(4-difluoromethyl-6-piperazin-1-yl[2,4']bipyridinyl-2'-yl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201673-40-6
tert-butyl 4-(2'-(cyclohexylamino)-4-(difluoromethyl)-2,4'-bipyridin-6-yl)piperazine-1-carboxylate

: 1201673-57-5
cyclohexyl-(4-difluoromethyl-6-piperazin-1-yl[2,4']bipyridinyl-2'-yl)amine

Guidance literature:: tert-butyl 4-(2'-(cyclohexylamino)-4-(difluoromethyl)-2,4'-bipyridin-6-yl)piperazine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With ammonia; In methanol; dichloromethane; at 20 ℃;
DOI:10.1021/jm100076w

Reference yield:

: 113293-70-2
2,6-dichloropyridine-4-carbaldehyde

: 1201673-57-5
cyclohexyl-(4-difluoromethyl-6-piperazin-1-yl[2,4']bipyridinyl-2'-yl)amine

Guidance literature:: Multi-step reaction with 4 steps

1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / Inert atmosphere

2: triethylamine / 1,4-dioxane / 48 h / 90 °C

3: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane

With diethylamino-sulfur trifluoride; triethylamine; cesium fluoride; trifluoroacetic acid; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1201675-01-5
2,6-dichloro-4-(difluoromethyl) pyridine

: 1201673-57-5
cyclohexyl-(4-difluoromethyl-6-piperazin-1-yl[2,4']bipyridinyl-2'-yl)amine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 1,4-dioxane / 48 h / 90 °C

2: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane

With triethylamine; cesium fluoride; trifluoroacetic acid; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane;