(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionic acid dodecyl ester

Base Information

• Chemical Name: (S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionic acid dodecyl ester
• CAS No.: 171671-71-9
• Molecular Formula: C₃₅H₅₂N₂O₅
• Molecular Weight: 580.808
• Mol file: 171671-71-9.mol

Synonyms:(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionic acid dodecyl ester

Chemical Property of (S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionic acid dodecyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionic acid dodecyl ester

There total 1 articles about (S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionic acid dodecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + dodecyl l-phenylalanine hydrochloride → (S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionic acid dodecyl ester (171671-71-9)

Guidance literature:

With diethyl cyanophosphonate; triethylamine; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/ja981363q

Reference yield:

(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionic acid dodecyl ester (171671-71-9) → (S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-phenyl-propionic acid dodecyl ester (741651-97-8)

Guidance literature:

With hydrogen bromide; acetic acid; In dichloromethane; for 4h;

DOI:10.1021/ja981363q

Reference yield:

(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionic acid dodecyl ester (171671-71-9) → (S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-phenyl-propionic acid dodecyl ester (770686-43-6)

Guidance literature:

Multi-step reaction with 3 steps

1: HBr, AcOH / CH₂Cl₂ / 4 h

2: Et₃N, diethyl phosphorocyanidate / tetrahydrofuran / Ambient temperature

3: HBr, AcOH / CH₂Cl₂ / 3 h

With diethyl cyanophosphonate; hydrogen bromide; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja981363q

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-phenyl-propionic acid dodecyl ester

(S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-phenyl-propionic acid dodecyl ester

(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-3-phenyl-propionic acid dodecyl ester

(S)-2-{(S)-2-[(S)-2-(11-Bromo-undecanoylamino)-3-phenyl-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propionic acid dodecyl ester