5-chloro-2-([(2-oxo([(3-pyridin-3-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid sodium salt

Base Information

Chemical Name:5-chloro-2-([(2-oxo([(3-pyridin-3-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid sodium salt
CAS No.:1190220-98-4
Molecular Formula:C₂₂H₁₇ClN₃O₅*Na
Molecular Weight:461.837
Hs Code.:

Synonyms:5-chloro-2-([(2-oxo([(3-pyridin-3-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid sodium salt

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Chemical Property of 5-chloro-2-([(2-oxo([(3-pyridin-3-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid sodium salt

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Technology Process of 5-chloro-2-([(2-oxo([(3-pyridin-3-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid sodium salt

There total 5 articles about 5-chloro-2-([(2-oxo([(3-pyridin-3-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1190222-00-4
methyl 5-chloro-2-{[(2-oxo-2-{[3-(pyridin-3-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

: 1190220-98-4
5-chloro-2-([(2-oxo([(3-pyridin-3-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid sodium salt

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 50 ℃; for 1h;
DOI:10.1016/j.bmcl.2017.11.016

Reference yield: 76.0%

: 1190220-98-4
5-chloro-2-([(2-oxo([(3-pyridin-3-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid sodium salt

Guidance literature:

Reference yield:

: 1103929-71-0
(2-{[4-chloro-2-(methoxycarbonyl)phenyl]amino}-2-oxoethoxy)acetic acid

: 1190220-98-4
5-chloro-2-([(2-oxo([(3-pyridin-3-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid sodium salt

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl acetamide / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; toluene; water / 7.5 h / Inert atmosphere; Reflux

3: sodium hydroxide; water / tetrahydrofuran / 1 h / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; toluene; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2017.11.016