methyl 5-chloro-2-{[(2-oxo-2-{[3-(pyridin-3-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

Base Information

Chemical Name:methyl 5-chloro-2-{[(2-oxo-2-{[3-(pyridin-3-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate
CAS No.:1190222-00-4
Molecular Formula:C₂₃H₂₀ClN₃O₅
Molecular Weight:453.882
Hs Code.:

Synonyms:methyl 5-chloro-2-{[(2-oxo-2-{[3-(pyridin-3-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

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Chemical Property of methyl 5-chloro-2-{[(2-oxo-2-{[3-(pyridin-3-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

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Technology Process of methyl 5-chloro-2-{[(2-oxo-2-{[3-(pyridin-3-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

There total 3 articles about methyl 5-chloro-2-{[(2-oxo-2-{[3-(pyridin-3-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1190221-99-8
methyl 2-[({2-[(3-bromophenyl)amino]-2-oxoethoxy}acetyl)amino]-5-chlorobenzoate

: 1692-25-7
3-pyridylboronic acid

: 1190222-00-4
methyl 5-chloro-2-{[(2-oxo-2-{[3-(pyridin-3-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethyl acetate; toluene; for 8h; Reflux;

Reference yield:

: 1103929-71-0
(2-{[4-chloro-2-(methoxycarbonyl)phenyl]amino}-2-oxoethoxy)acetic acid

: 1190222-00-4
methyl 5-chloro-2-{[(2-oxo-2-{[3-(pyridin-3-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl acetamide / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; toluene; water / 7.5 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl acetamide; water; toluene; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2017.11.016

Reference yield:

: 591-19-5
m-Bromoaniline

: 1190222-00-4
methyl 5-chloro-2-{[(2-oxo-2-{[3-(pyridin-3-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl acetamide / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; toluene; water / 7.5 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl acetamide; water; toluene; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2017.11.016