5-(N-trifluoroacetamidomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-cyanoethoxy-N,N'-diisopropylaminophosphinyl)uridine

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Chemical Name:5-(N-trifluoroacetamidomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-cyanoethoxy-N,N'-diisopropylaminophosphinyl)uridine
CAS No.:1370546-06-7
Molecular Formula:C₄₂H₄₉F₃N₅O₉P
Molecular Weight:855.848
Hs Code.:

Synonyms:5-(N-trifluoroacetamidomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-cyanoethoxy-N,N'-diisopropylaminophosphinyl)uridine

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Chemical Property of 5-(N-trifluoroacetamidomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-cyanoethoxy-N,N'-diisopropylaminophosphinyl)uridine

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Technology Process of 5-(N-trifluoroacetamidomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-cyanoethoxy-N,N'-diisopropylaminophosphinyl)uridine

There total 3 articles about 5-(N-trifluoroacetamidomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-cyanoethoxy-N,N'-diisopropylaminophosphinyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1370546-05-6
5-(N-trifluoroacetamidomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1370546-06-7
5-(N-trifluoroacetamidomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-cyanoethoxy-N,N'-diisopropylaminophosphinyl)uridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2012.03.024

Reference yield:

: 137552-29-5
5-(azidomethyl)-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyuridine

: 1370546-06-7
5-(N-trifluoroacetamidomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-cyanoethoxy-N,N'-diisopropylaminophosphinyl)uridine

Guidance literature:: Multi-step reaction with 3 steps

1: 5%-palladium/activated carbon; hydrogen / methanol / 12 h / 20 °C

2: pyridine / 5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With pyridine; 5%-palladium/activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.03.024

Reference yield:

: 137568-57-1
5-(aminomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

: 1370546-06-7
5-(N-trifluoroacetamidomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-cyanoethoxy-N,N'-diisopropylaminophosphinyl)uridine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2012.03.024