(R)-(3-{5-[(S)-((R)-2-Amino-3-phenyl-propionylamino)-methoxycarbonyl-methyl]-3-methoxy-2-methyl-phenoxy}-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid

Base Information

Chemical Name:(R)-(3-{5-[(S)-((R)-2-Amino-3-phenyl-propionylamino)-methoxycarbonyl-methyl]-3-methoxy-2-methyl-phenoxy}-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid
CAS No.:1027065-47-9
Molecular Formula:C₃₄H₄₁N₃O₁₀
Molecular Weight:651.714
Hs Code.:

(R)-(3-{5-[(S)-((R)-2-Amino-3-phenyl-propionylamino)-methoxycarbonyl-methyl]-3-methoxy-2-methyl-phenoxy}-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid

Synonyms:(R)-(3-{5-[(S)-((R)-2-Amino-3-phenyl-propionylamino)-methoxycarbonyl-methyl]-3-methoxy-2-methyl-phenoxy}-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid

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Chemical Property of (R)-(3-{5-[(S)-((R)-2-Amino-3-phenyl-propionylamino)-methoxycarbonyl-methyl]-3-methoxy-2-methyl-phenoxy}-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid

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Technology Process of (R)-(3-{5-[(S)-((R)-2-Amino-3-phenyl-propionylamino)-methoxycarbonyl-methyl]-3-methoxy-2-methyl-phenoxy}-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid

There total 8 articles about (R)-(3-{5-[(S)-((R)-2-Amino-3-phenyl-propionylamino)-methoxycarbonyl-methyl]-3-methoxy-2-methyl-phenoxy}-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 1027065-47-9
(R)-(3-{5-[(S)-((R)-2-Amino-3-phenyl-propionylamino)-methoxycarbonyl-methyl]-3-methoxy-2-methyl-phenoxy}-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: EDC, HOBT / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) room temp., 15 min

2: MgBr₂*Et₂O / CH₂Cl₂ / 36 h / Ambient temperature

3: H₂ / Pd-C / ethanol / 1 h

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; magnesium bromide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jo00088a010

Reference yield:

: 159579-77-8
(R)-(3-{5-[(S)-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-methoxycarbonyl-methyl]-3-methoxy-2-methyl-phenoxy}-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid

: 1027065-47-9
(R)-(3-{5-[(S)-((R)-2-Amino-3-phenyl-propionylamino)-methoxycarbonyl-methyl]-3-methoxy-2-methyl-phenoxy}-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 1h;
DOI:10.1021/jo00088a010

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1027065-47-9
(R)-(3-{5-[(S)-((R)-2-Amino-3-phenyl-propionylamino)-methoxycarbonyl-methyl]-3-methoxy-2-methyl-phenoxy}-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 10percent Pd-C / tetrahydrofuran / 38 h

3: EDC, HOBT / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) room temp., 15 min

4: MgBr₂*Et₂O / CH₂Cl₂ / 36 h / Ambient temperature

5: H₂ / Pd-C / ethanol / 1 h

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; magnesium bromide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00088a010