(4S,5S)-2-(4-bromobenzyl)-5-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-6-phenylhexanoic Acid

Base Information

Chemical Name:(4S,5S)-2-(4-bromobenzyl)-5-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-6-phenylhexanoic Acid
CAS No.:854757-16-7
Molecular Formula:C₃₀H₄₄BrNO₅Si
Molecular Weight:606.673
Hs Code.:

Synonyms:(4S,5S)-2-(4-bromobenzyl)-5-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-6-phenylhexanoic Acid

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Chemical Property of (4S,5S)-2-(4-bromobenzyl)-5-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-6-phenylhexanoic Acid

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Technology Process of (4S,5S)-2-(4-bromobenzyl)-5-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-6-phenylhexanoic Acid

There total 1 articles about (4S,5S)-2-(4-bromobenzyl)-5-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-6-phenylhexanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: C₂₄H₃₀BrNO₅

: 18162-48-6
tert-butyldimethylsilyl chloride

: 854757-16-7
(4S,5S)-2-(4-bromobenzyl)-5-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-6-phenylhexanoic Acid

Guidance literature:: C₂₄H₃₀BrNO₅; tert-butyldimethylsilyl chloride; With 1H-imidazole; In 1,4-dioxane; at 25 ℃; for 18h;

With hydrogenchloride; In 1,4-dioxane; water; pH=3;

Reference yield: 19.0%

: 854757-16-7
(4S,5S)-2-(4-bromobenzyl)-5-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-6-phenylhexanoic Acid

: 100-51-6,185532-71-2
benzyl alcohol

: 854757-20-3
tert-butyl (1S,2S,4R)-1-benzyl-4-{[(benzyloxy)carbonyl]amino}-5-(4-bromophenyl)-2-{[tert-butyl(dimethyl)silyl]oxy}pentylcarbamate

Guidance literature:: (4S,5S)-2-(4-bromobenzyl)-5-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-6-phenylhexanoic Acid; With diphenylphosphoranyl azide; triethylamine; In toluene; for 2h; Heating / reflux;

benzyl alcohol; In toluene; for 16h; Heating / reflux;

Reference yield: 18.0%

: 854757-16-7
(4S,5S)-2-(4-bromobenzyl)-5-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-6-phenylhexanoic Acid

: 100-51-6,185532-71-2
benzyl alcohol

: 854757-18-9
tert-butyl (1S,2S,4S)-1-benzyl-4-{[benzyloxycarbonyl]amino}-5-(4-bromophenyl)-2-{[tert-butyl(dimethyl)silyl]oxy}pentylcarbamate

Guidance literature:: (4S,5S)-2-(4-bromobenzyl)-5-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-6-phenylhexanoic Acid; With diphenylphosphoranyl azide; triethylamine; In toluene; for 2h; Heating / reflux;

benzyl alcohol; In toluene; for 16h; Heating / reflux;