[9-[[3-[2-(benzylamino)ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

Base Information

Chemical Name:[9-[[3-[2-(benzylamino)ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone
CAS No.:1414360-83-0
Molecular Formula:C₃₁H₃₉FN₄O₂S
Molecular Weight:550.741
Hs Code.:

Synonyms:[9-[[3-[2-(benzylamino)ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

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Chemical Property of [9-[[3-[2-(benzylamino)ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

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Technology Process of [9-[[3-[2-(benzylamino)ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

There total 8 articles about [9-[[3-[2-(benzylamino)ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1414360-76-1
2-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]acetaldehyde

: 100-46-9
benzylamine

: 1414360-83-0
[9-[[3-[2-(benzylamino)ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

Guidance literature:: With hydrogen; 5% Ir/CaCO3; In ethanol; at 40 ℃; for 16h; under 3000.3 Torr;

Reference yield:

: tert-butyl 7-oxa-3,10-diazaspiro[5.5]undecane-3-carboxylate hydrochloride

: 1414360-83-0
[9-[[3-[2-(benzylamino)ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran; 2-methyltetrahydrofuran / 1 h / 5 - 20 °C / Industry scale

2.1: hydrogenchloride; isopropyl alcohol / tert-butyl methyl ether; 2-methyltetrahydrofuran / 28 h / 20 - 40 °C / Industry scale

3.1: sodium hydroxide / water; 2-methyltetrahydrofuran / 0.33 h / 20 °C / Industry scale

4.1: sodium carbonate / toluene; water / 15 - 20 °C / Industry scale

4.2: 15 - 20 °C / Industry scale

5.1: hydrogenchloride / water; 2-methyltetrahydrofuran / 2.5 h / 50 °C / Industry scale

5.2: Industry scale

6.1: hydrogen / 5% Ir/CaCO3 / ethanol / 16 h / 40 °C / 3000.3 Torr

With hydrogenchloride; hydrogen; sodium carbonate; triethylamine; isopropyl alcohol; sodium hydroxide; 5% Ir/CaCO3; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; tert-butyl methyl ether; water; toluene;

Reference yield:

: (2-isopropylthiazol-4-yl)-(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone dihydrochloride

: 1414360-83-0
[9-[[3-[2-(benzylamino)ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water; 2-methyltetrahydrofuran / 0.33 h / 20 °C / Industry scale

2.1: sodium carbonate / toluene; water / 15 - 20 °C / Industry scale

2.2: 15 - 20 °C / Industry scale

3.1: hydrogenchloride / water; 2-methyltetrahydrofuran / 2.5 h / 50 °C / Industry scale

3.2: Industry scale

4.1: hydrogen / 5% Ir/CaCO3 / ethanol / 16 h / 40 °C / 3000.3 Torr

With hydrogenchloride; hydrogen; sodium carbonate; sodium hydroxide; 5% Ir/CaCO3; In 2-methyltetrahydrofuran; ethanol; water; toluene;