[9-[[3-[2-[benzyl-[(2R)-2-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)-2-hydroxyethyl]amino]ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

Base Information

Chemical Name:[9-[[3-[2-[benzyl-[(2R)-2-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)-2-hydroxyethyl]amino]ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone
CAS No.:1414360-85-2
Molecular Formula:C₄₇H₆₀FN₅O₅S₂
Molecular Weight:858.154
Hs Code.:

[9-[[3-[2-[benzyl-[(2R)-2-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)-2-hydroxyethyl]amino]ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

Synonyms:[9-[[3-[2-[benzyl-[(2R)-2-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)-2-hydroxyethyl]amino]ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

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Chemical Property of [9-[[3-[2-[benzyl-[(2R)-2-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)-2-hydroxyethyl]amino]ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

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Technology Process of [9-[[3-[2-[benzyl-[(2R)-2-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)-2-hydroxyethyl]amino]ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

There total 15 articles about [9-[[3-[2-[benzyl-[(2R)-2-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)-2-hydroxyethyl]amino]ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1414360-84-1
2-[benzyl-[2-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethyl]amino]-1-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)ethanone

: 1414360-85-2
[9-[[3-[2-[benzyl-[(2R)-2-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)-2-hydroxyethyl]amino]ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

Guidance literature:: With formic acid; triethylamine; N-[(1S,2S)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; In isopropyl alcohol;

Reference yield:

: 1179337-61-1
[3-[[4-fluoro-3-[2-methoxyvinyl]phenyl]methyl]-7-oxa-3,10-diazaspiro[5.5]undecan-10-yl]-(2-isopropylthiazol-4-yl)methanone

: 1414360-85-2
[9-[[3-[2-[benzyl-[(2R)-2-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)-2-hydroxyethyl]amino]ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water; 2-methyltetrahydrofuran / 2.5 h / 50 °C / Industry scale

1.2: Industry scale

2.1: hydrogen / 5% Ir/CaCO3 / ethanol / 16 h / 40 °C / 3000.3 Torr

3.1: sodium hexamethyldisilazane / Methyl isobutyl carbinol / 1 h / 60 °C / Inert atmosphere

3.2: 16 h / 120 °C / Inert atmosphere

With hydrogenchloride; hydrogen; sodium hexamethyldisilazane; 5% Ir/CaCO3; In 2-methyltetrahydrofuran; Methyl isobutyl carbinol; ethanol; water;

Reference yield:

: 234445-61-5
2-isopropyl-1,3-thiazol-4-carboxylic acid

: 1414360-85-2
[9-[[3-[2-[benzyl-[(2R)-2-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)-2-hydroxyethyl]amino]ethyl]-4-fluorophenyl]methyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-(2-isopropylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran; 2-methyltetrahydrofuran / 1 h / 5 - 20 °C / Industry scale

2.1: hydrogenchloride; isopropyl alcohol / tert-butyl methyl ether; 2-methyltetrahydrofuran / 28 h / 20 - 40 °C / Industry scale

3.1: sodium hydroxide / water; 2-methyltetrahydrofuran / 0.33 h / 20 °C / Industry scale

4.1: sodium carbonate / toluene; water / 15 - 20 °C / Industry scale

4.2: 15 - 20 °C / Industry scale

5.1: hydrogenchloride / water; 2-methyltetrahydrofuran / 2.5 h / 50 °C / Industry scale

5.2: Industry scale

6.1: hydrogen / 5% Ir/CaCO3 / ethanol / 16 h / 40 °C / 3000.3 Torr

7.1: sodium hexamethyldisilazane / Methyl isobutyl carbinol / 1 h / 60 °C / Inert atmosphere

7.2: 16 h / 120 °C / Inert atmosphere

With hydrogenchloride; hydrogen; sodium hexamethyldisilazane; sodium carbonate; triethylamine; isopropyl alcohol; sodium hydroxide; 5% Ir/CaCO3; In tetrahydrofuran; 2-methyltetrahydrofuran; Methyl isobutyl carbinol; ethanol; tert-butyl methyl ether; water; toluene;