methyl 2-(((3aR,4S,6R,6aS)-6-(7-(N-((1R,2S)-2-(3,4-difluoro-phenyl)cyclopropyl)-4-methylphenylsulfonamido)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

Base Information

Chemical Name:methyl 2-(((3aR,4S,6R,6aS)-6-(7-(N-((1R,2S)-2-(3,4-difluoro-phenyl)cyclopropyl)-4-methylphenylsulfonamido)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate
CAS No.:1427524-33-1
Molecular Formula:C₃₄H₃₈F₂N₆O₇S₂
Molecular Weight:744.841
Hs Code.:

methyl 2-(((3aR,4S,6R,6aS)-6-(7-(N-((1R,2S)-2-(3,4-difluoro-phenyl)cyclopropyl)-4-methylphenylsulfonamido)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

Synonyms:methyl 2-(((3aR,4S,6R,6aS)-6-(7-(N-((1R,2S)-2-(3,4-difluoro-phenyl)cyclopropyl)-4-methylphenylsulfonamido)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

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Chemical Property of methyl 2-(((3aR,4S,6R,6aS)-6-(7-(N-((1R,2S)-2-(3,4-difluoro-phenyl)cyclopropyl)-4-methylphenylsulfonamido)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

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Technology Process of methyl 2-(((3aR,4S,6R,6aS)-6-(7-(N-((1R,2S)-2-(3,4-difluoro-phenyl)cyclopropyl)-4-methylphenylsulfonamido)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

There total 7 articles about methyl 2-(((3aR,4S,6R,6aS)-6-(7-(N-((1R,2S)-2-(3,4-difluoro-phenyl)cyclopropyl)-4-methylphenylsulfonamido)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1427523-89-4
N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-N-(3-((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-4-methylbenzenesulfonamide

: 96-32-2
bromoacetic acid methyl ester

: 1427524-33-1
methyl 2-(((3aR,4S,6R,6aS)-6-(7-(N-((1R,2S)-2-(3,4-difluoro-phenyl)cyclopropyl)-4-methylphenylsulfonamido)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

Guidance literature:: N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-N-(3-((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-4-methylbenzenesulfonamide; With sodium hydride; In tetrahydrofuran; at -20 ℃; for 0.333333h;

bromoacetic acid methyl ester; In tetrahydrofuran; at -20 ℃; for 18h;

Reference yield:

: 1427523-83-8
N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzene sulfonamide

: 1427524-33-1
methyl 2-(((3aR,4S,6R,6aS)-6-(7-(N-((1R,2S)-2-(3,4-difluoro-phenyl)cyclopropyl)-4-methylphenylsulfonamido)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate / acetonitrile / 24 h / 25 °C

2.1: sodium hydride / tetrahydrofuran / 0.33 h / -20 °C

2.2: 18 h / -20 °C

With potassium phosphate; sodium hydride; In tetrahydrofuran; acetonitrile;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1427524-33-1
methyl 2-(((3aR,4S,6R,6aS)-6-(7-(N-((1R,2S)-2-(3,4-difluoro-phenyl)cyclopropyl)-4-methylphenylsulfonamido)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 1.5 h / Cooling with ice

2.1: potassium phosphate / acetonitrile / 24 h / 25 °C

3.1: sodium hydride / tetrahydrofuran / 0.33 h / -20 °C

3.2: 18 h / -20 °C

With potassium phosphate; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;