O-1-(2-nitrophenyl)ethyl-O'-β-cyanoethyl-N,N-diisopropylphosphoramidite

Base Information

Chemical Name:O-1-(2-nitrophenyl)ethyl-O'-β-cyanoethyl-N,N-diisopropylphosphoramidite
CAS No.:461425-49-0
Molecular Formula:C₁₇H₂₆N₃O₄P
Molecular Weight:367.385
Hs Code.:

Synonyms:O-1-(2-nitrophenyl)ethyl-O'-β-cyanoethyl-N,N-diisopropylphosphoramidite

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of O-1-(2-nitrophenyl)ethyl-O'-β-cyanoethyl-N,N-diisopropylphosphoramidite

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Technology Process of O-1-(2-nitrophenyl)ethyl-O'-β-cyanoethyl-N,N-diisopropylphosphoramidite

There total 3 articles about O-1-(2-nitrophenyl)ethyl-O'-β-cyanoethyl-N,N-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 80379-10-8,108530-03-6,142631-59-2,3205-25-2
1-(2-nitrophenyl)ethan-1-ol

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 461425-49-0
O-1-(2-nitrophenyl)ethyl-O'-β-cyanoethyl-N,N-diisopropylphosphoramidite

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201103833

Reference yield:

: 577-59-3
2-acetylnitrobenzene

: 461425-49-0
O-1-(2-nitrophenyl)ethyl-O'-β-cyanoethyl-N,N-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 97.9 percent / sodium borohydride / methanol; dioxane / 2.5 h / 20 °C

2: triethylamine / CH₂Cl₂ / 20 °C

With sodium tetrahydroborate; triethylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/ol0262587