2,3,5-Trichloro-6-methoxypyridine

Base Information

• Chemical Name: 2,3,5-Trichloro-6-methoxypyridine
• CAS No.: 31557-34-3
• Molecular Formula: C6H4 Cl3 N O
• Molecular Weight: 212.463
• Hs Code.: 2933399090
• European Community (EC) Number: 250-697-2
• UNII: HRT7GB596J
• DSSTox Substance ID: DTXSID90185456
• Nikkaji Number: J278.144A
• Wikidata: Q27280065
• Mol file: 31557-34-3.mol

Synonyms:2-methoxy-3,5,6-trichloropyridine

Chemical Property of 2,3,5-Trichloro-6-methoxypyridine

Chemical Property:

• Vapor Pressure: 0.0655mmHg at 25°C
• Boiling Point: 238.4°Cat760mmHg
• Flash Point: 98°C
• PSA: 22.12000
• Density: 1.49g/cm³
• LogP: 3.05040
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 210.935847
• Heavy Atom Count: 11
• Complexity: 135

Purity/Quality:

99% ^*data from raw suppliers

2,3,5-Trichloro-6-methoxypyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC(=C(C=C1Cl)Cl)Cl

Technology Process of 2,3,5-Trichloro-6-methoxypyridine

There total 2 articles about 2,3,5-Trichloro-6-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5,6-trichloropyridine-2-one (6515-38-4) + methyl iodide (74-88-4) → 2-methoxy-3,5,6-trichloropyridine (31557-34-3) + 3,5,6-trichloro-1-methyl-2-pyridone (75348-52-6)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Product distribution; Heating; other alkyl halides and acyl chlorides, other conditions;

Reference yield:

→ 2-methoxy-3,5,6-trichloropyridine (31557-34-3)

Guidance literature:

6-Methoxytetrachlorpyridin, n-BuLi;

DOI:10.1039/j39710001227

upstream raw materials:

3,5,6-trichloropyridine-2-one

methyl iodide

Refernces

• 1、 Neelakantan, Parvathi,Rani, Renu,Rahman, M. F.,Bhalerao, U. T.. "Alkylation and Acylation of 3,5,6-Trichloropyridine-2-one and 2-Isopropyl-6-methylpyrimidine-4-one". . p. 1180 - 1181. Retrieved 2007/10/02.