(3S)-1-[(2S,3S)-2-amino-3-[4-(5-bromo-6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine trifluoroacetic acid salt

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Chemical Name:(3S)-1-[(2S,3S)-2-amino-3-[4-(5-bromo-6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine trifluoroacetic acid salt
CAS No.:690256-63-4
Molecular Formula:C₂HF₃O₂*C₁₉H₂₁BrFN₃O₂
Molecular Weight:536.321
Hs Code.:

Synonyms:(3S)-1-[(2S,3S)-2-amino-3-[4-(5-bromo-6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine trifluoroacetic acid salt

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Chemical Property of (3S)-1-[(2S,3S)-2-amino-3-[4-(5-bromo-6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine trifluoroacetic acid salt

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Technology Process of (3S)-1-[(2S,3S)-2-amino-3-[4-(5-bromo-6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine trifluoroacetic acid salt

There total 8 articles about (3S)-1-[(2S,3S)-2-amino-3-[4-(5-bromo-6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 690257-88-6
(3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine

: 76-05-1
trifluoroacetic acid

: 690256-63-4
(3S)-1-[(2S,3S)-2-amino-3-[4-(5-bromo-6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine trifluoroacetic acid salt

Guidance literature:: (3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine; With pyridinium hydrobromide perbromide; In dichloromethane; at 20 ℃; for 2h;

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 690257-80-8
(4R)-3-[(2R,3S)-2-bromo-3-(4-bromophenyl)butanoyl]-4-phenyl-1,3-oxazolidin-2-one

: 690256-63-4
(3S)-1-[(2S,3S)-2-amino-3-[4-(5-bromo-6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetramethylguanidinum azide / acetonitrile / 12 h / 20 °C

2.1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 4.25 h / 0 °C

3.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 12 h / 20 °C

3.2: 12 h / 90 °C

3.3: 12 h / 20 °C

4.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 12 h / 90 °C

5.1: pyridine hydrochloride / 0.33 h / 160 °C / Neat (no solvent)

5.2: 12 h / 20 °C

6.1: pyridinium hydrobromide perbromide / dichloromethane / 2 h / 20 °C

6.2: 1 h / 20 °C

With lithium hydroxide; pyridinium hydrobromide perbromide; dihydrogen peroxide; pyridine hydrochloride; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; tetramethylguanidinum azide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water; toluene; acetonitrile; 4.1: Suzuki Coupling;

Reference yield:

: 690257-78-4
(R)-3-(3-(4-bromophenyl)acryloyl)-4-phenyloxazolidin-2-one

: 690256-63-4
(3S)-1-[(2S,3S)-2-amino-3-[4-(5-bromo-6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper (II) bromide dimethylsulfide / tetrahydrofuran; dimethylsulfide; diethyl ether / 0.5 h / -40 °C

1.2: 15 h / -20 - 20 °C

2.1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / -78 - 0 °C

2.2: 4 h / -78 - 0 °C

3.1: tetramethylguanidinum azide / acetonitrile / 12 h / 20 °C

4.1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 4.25 h / 0 °C

5.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 12 h / 20 °C

5.2: 12 h / 90 °C

5.3: 12 h / 20 °C

6.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 12 h / 90 °C

7.1: pyridine hydrochloride / 0.33 h / 160 °C / Neat (no solvent)

7.2: 12 h / 20 °C

8.1: pyridinium hydrobromide perbromide / dichloromethane / 2 h / 20 °C

8.2: 1 h / 20 °C

With lithium hydroxide; pyridinium hydrobromide perbromide; copper (II) bromide dimethylsulfide; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; pyridine hydrochloride; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; tetramethylguanidinum azide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dimethylsulfide; diethyl ether; ethanol; dichloromethane; water; toluene; acetonitrile; 6.1: Suzuki Coupling;