Carbamic acid, [(1S,2S)-2-[4-(1,6-dihydro-6-oxo-3-pyridinyl)phenyl]-1-[[(3S)-3-fluoro-1- pyrrolidinyl]carbonyl]propyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S,2S)-2-[4-(1,6-dihydro-6-oxo-3-pyridinyl)phenyl]-1-[[(3S)-3-fluoro-1- pyrrolidinyl]carbonyl]propyl]-, 1,1-dimethylethyl ester
CAS No.:690257-88-6
Molecular Formula:C24H30FN3O4
Molecular Weight:443.518
Hs Code.:

Carbamic acid,
[(1S,2S)-2-[4-(1,6-dihydro-6-oxo-3-pyridinyl)phenyl]-1-[[(3S)-3-fluoro-1-
pyrrolidinyl]carbonyl]propyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [(1S,2S)-2-[4-(1,6-dihydro-6-oxo-3-pyridinyl)phenyl]-1-[[(3S)-3-fluoro-1- pyrrolidinyl]carbonyl]propyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(1S,2S)-2-[4-(1,6-dihydro-6-oxo-3-pyridinyl)phenyl]-1-[[(3S)-3-fluoro-1- pyrrolidinyl]carbonyl]propyl]-, 1,1-dimethylethyl ester

There total 10 articles about Carbamic acid, [(1S,2S)-2-[4-(1,6-dihydro-6-oxo-3-pyridinyl)phenyl]-1-[[(3S)-3-fluoro-1- pyrrolidinyl]carbonyl]propyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 876625-74-0
(3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(6-methoxypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine

: 690257-88-6
(3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine

Guidance literature:: With pyridine hydrochloride; at 190 ℃;
DOI:10.1016/j.bmcl.2005.11.052

Reference yield:

: 690257-83-1
(3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-(4-bromophenyl)-1-oxobutanyl]-3-fluoropyrrolidine

: 690257-88-6
(3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: aq. Na₂CO₃; Pd(dppf)2Cl₂ / toluene; ethanol / 90 °C

2: Py*HCl / 190 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; pyridine hydrochloride; sodium carbonate; In ethanol; toluene; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2005.11.052

Reference yield:

: 690257-82-0
(2R,3S)-2-azido-3-(4-bromophenyl)butanoic acid

: 690257-88-6
(3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 12 h / 20 °C

1.2: 12 h / 90 °C

1.3: 12 h / 20 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 12 h / 90 °C

3.1: pyridine hydrochloride / 0.33 h / 160 °C / Neat (no solvent)

3.2: 12 h / 20 °C

With pyridine hydrochloride; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In DMF (N,N-dimethyl-formamide); ethanol; water; toluene; 2.1: Suzuki Coupling;