2,2-DIMETHYLCHROMANE

Base Information

• Chemical Name: 2,2-DIMETHYLCHROMANE
• CAS No.: 1198-96-5
• Molecular Formula: C11H14 O
• Molecular Weight: 162.232
• Hs Code.: 2932999099
• Mol file: 1198-96-5.mol

Synonyms:Chroman,2,2-dimethyl- (6CI,7CI,8CI); 2,2-Dimethyl-3,4-dihydrobenzopyran;2,2-Dimethylchroman; 2,2-Dimethylchromane; 3,4-Dihydro-2,2-dimethyl-2H-1-benzopyran;NSC 63863

Chemical Property of 2,2-DIMETHYLCHROMANE

Chemical Property:

• Vapor Pressure: 0.112mmHg at 25°C
• Refractive Index: 1.5400 (estimate)
• Boiling Point: 228.3°Cat760mmHg
• Flash Point: 84.8°C
• PSA: 9.23000
• Density: 0.978g/cm³
• LogP: 2.79020
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,2-Dimethylchroman ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,2-Dimethylchroman is a reagent used in the identification of retinoic acid receptor antagonists.

Technology Process of 2,2-DIMETHYLCHROMANE

There total 66 articles about 2,2-DIMETHYLCHROMANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(2-hydroxyphenyl)-2-methyl-2-butanol (4167-73-1) → 2,2-dimethylchroman (1198-96-5)

Guidance literature:

With sulfuric acid; In benzene; at 105 ℃; for 2h;

DOI:10.1021/jm9703911

Reference yield: 99.0%

2-prenylphenol (1128-92-3) → 2,2-dimethylchroman (1198-96-5)

Guidance literature:

With Fe doped montmorillonite (Fe-MMT); at 80 ℃; for 24h; Reagent/catalyst; regioselective reaction; Schlenk technique; Sealed tube;

DOI:10.1039/c5ra25176a

Reference yield: 80.0%

phenyl prenyl ether (14309-15-0) → 2,2-dimethylchroman (1198-96-5)

Guidance literature:

With silica gel; at 70 ℃; for 2.5h;

DOI:10.1007/BF00961527

upstream raw materials:

Ketene

2-prenylphenol

2,2-dimethyl-2H-chromene

4-(2-hydroxyphenyl)-2-methyl-2-butanol

Downstream raw materials:

3,4-dihydro-2,2-dimethyl-8-carboxy-2H-1-benzopyran

3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-carboxaldehyde

2-(3-chloro-3-methylbutyl)phenol

cis-octahydro-2,2-dimethyl-1-benzopyran

Refernces

• 1、 Shelby,Kataoka,Mann,Hartwig. "Unusual in situ ligand modification to generate a catalyst for room temperature aromatic C-O bond formation [8]". . p. 10718 - 10719. Retrieved 2000.
• 2、 Fatope,Abraham. "Design, synthesis, and testing of potential antisickling agents. 10. (2,2-Dimethylchroman-6-yl)alkanoic acids". . p. 1973 - 1977. Retrieved 1987.
• 3、 Claisen. "-". . p. 200. Retrieved 1921.
• 4、 Palucki, Michael,Wolfe, John P.,Buchwald, Stephen L.. "Synthesis of oxygen heterocycles via a pallidium-catalyzed C-O bond-forming reaction". . p. 10333 - 10334. Retrieved 1996.
• 5、 Smit, V. A.,Pogrebnoi, S. I.,Kal'yan, Yu. B.,Krimer, M. Z.. "CLAISEN REARRANGEMENT OF ALLYL ARYL ETHERS UNDER ADSORPTION CONDITIONS". . p. 1760 - 1761. Retrieved 1990.
• 6、 -. "RAR-ALPHA COMPOUNDS FOR INFLAMMATORY DISEASE AND MALE CONTRACEPTION". Paragraph 0107-0108. . Retrieved 2021/06/26.
• 7、 Chou, Ting-Hung,Yu, Bo-Hung,Chein, Rong-Jie. "ZnI2/Zn(OTf)2-TsOH: A versatile combined-Acid system for catalytic intramolecular hydrofunctionalization and polyene cyclization". supporting information. p. 13522 - 13525. Retrieved 2019/11/14.