N-(cyclopropylmethyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-amine

Base Information

Chemical Name:N-(cyclopropylmethyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-amine
CAS No.:1220706-91-1
Molecular Formula:C₁₈H₂₉N₃O
Molecular Weight:303.448
Hs Code.:

Synonyms:N-(cyclopropylmethyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(cyclopropylmethyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-amine

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Technology Process of N-(cyclopropylmethyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-amine

There total 4 articles about N-(cyclopropylmethyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 20529-23-1
3-(4-(2-methoxyphenyl)piperazin-1-yl)propylamine

: 1489-69-6
Cyclopropanecarboxaldehyde

: 1220706-91-1
N-(cyclopropylmethyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2009.12.067

Reference yield:

: 21279-77-6
1-(2-methoxyphenyl)-4-(3-chloropropyl)piperazine

: 2516-47-4
cyclopropanemethylamine

: 1220706-91-1
N-(cyclopropylmethyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-amine

Guidance literature:: With potassium carbonate; In acetonitrile; for 8h;
DOI:10.1016/j.ejmech.2020.112214

Reference yield:

: 3-Chloro-1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propan-1-one

: 1220706-91-1
N-(cyclopropylmethyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 2.5 h / 0 - 70 °C / Inert atmosphere

1.2: 1 h / 70 °C / Inert atmosphere

2.1: potassium carbonate / acetonitrile / 8 h

With dimethylsulfide borane complex; potassium carbonate; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.ejmech.2020.112214