1-(2-METHOXYPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE DIHYDROCHLORIDE

Base Information

• Chemical Name: 1-(2-METHOXYPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE DIHYDROCHLORIDE
• CAS No.: 21279-77-6
• Molecular Formula: C14H21 Cl N2 O
• Molecular Weight: 268.787
• Hs Code.: 2933599590
• Mol file: 21279-77-6.mol

Synonyms:Piperazine,1-(3-chloropropyl)-4-(o-methoxyphenyl)- (8CI);1-(3-Chloropropyl)-4-(2-methoxyphenyl)piperazine

Chemical Property of 1-(2-METHOXYPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE DIHYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 2.21E-06mmHg at 25°C
• Melting Point: 225°C (dec.)
• Boiling Point: 392.9°Cat760mmHg
• PKA: 7.28±0.10(Predicted)
• Flash Point: 191.4°C
• PSA: 15.71000
• Density: g/cm³
• LogP: 4.05300

Purity/Quality:

97% ^*data from raw suppliers

1-(3-Chloropropyl)-4-(2-methoxyphenyl)piperazine dihydrochloride 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-METHOXYPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE DIHYDROCHLORIDE

There total 10 articles about 1-(2-METHOXYPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(2-Methoxyphenyl)piperazine (35386-24-4) + 1-iodo-3-chloro-propane (6940-76-7) → 1-(2-methoxyphenyl)-4-(3-chloropropyl)piperazine (21279-77-6)

Guidance literature:

With potassium carbonate; In acetonitrile; at 25 ℃; for 12h;

DOI:10.1039/d1cc02665h

Reference yield: 87.0%

3-[4-(2-methoxyphenyl)piperazin-1-yl]-1-propanol (41103-43-9) → 1-(2-methoxyphenyl)-4-(3-chloropropyl)piperazine (21279-77-6)

Guidance literature:

With thionyl chloride; In chloroform; at 0 - 100 ℃; for 6h;

DOI:10.1021/jacs.9b05221

Reference yield: 79.0%

1-(2-Methoxyphenyl)piperazine (35386-24-4) + 1.3-chlorobromopropane (109-70-6) → 1-(2-methoxyphenyl)-4-(3-chloropropyl)piperazine (21279-77-6)

Guidance literature:

With sodium hydroxide; In acetone; at 20 ℃; for 48h;

upstream raw materials:

1-(2-Methoxyphenyl)piperazine

1.3-chlorobromopropane

1-(2-methoxyphenyl)piperazine hydrochloride

2-methoxy-phenylamine

Downstream raw materials:

3-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-3H-benzo[d][1,2,3]triazin-4-one

1-(4-nitrophenoxy)-3-1-(N⁴-(2-methoxyphenyl)piperazinyl)>propane

1-(6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propoxy}-3,4-dihydro-2H-quinolin-1-yl)-ethanone

1-[3-(4-Bromo-phenoxy)-propyl]-4-(2-methoxy-phenyl)-piperazine

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