(3S,3aR)-3a-(methoxymethyl)-3-phenyl-2-tosyl-2,3,3a,4-tetrahydro-1H-benzo[f]isoindole

Base Information

Chemical Name:(3S,3aR)-3a-(methoxymethyl)-3-phenyl-2-tosyl-2,3,3a,4-tetrahydro-1H-benzo[f]isoindole
CAS No.:1426341-82-3
Molecular Formula:C₂₇H₂₇NO₃S
Molecular Weight:445.582
Hs Code.:

Synonyms:(3S,3aR)-3a-(methoxymethyl)-3-phenyl-2-tosyl-2,3,3a,4-tetrahydro-1H-benzo[f]isoindole

Suppliers and Price of (3S,3aR)-3a-(methoxymethyl)-3-phenyl-2-tosyl-2,3,3a,4-tetrahydro-1H-benzo[f]isoindole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,3aR)-3a-(methoxymethyl)-3-phenyl-2-tosyl-2,3,3a,4-tetrahydro-1H-benzo[f]isoindole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,3aR)-3a-(methoxymethyl)-3-phenyl-2-tosyl-2,3,3a,4-tetrahydro-1H-benzo[f]isoindole

There total 3 articles about (3S,3aR)-3a-(methoxymethyl)-3-phenyl-2-tosyl-2,3,3a,4-tetrahydro-1H-benzo[f]isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1426342-12-2
(3S,3aS)-5,5-dibutyl-3a-(methoxymethyl)-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole

: 583-53-9
2,3-dibromobenzene

: 1426341-82-3
(3S,3aR)-3a-(methoxymethyl)-3-phenyl-2-tosyl-2,3,3a,4-tetrahydro-1H-benzo[f]isoindole

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; for 20h; Inert atmosphere; Reflux;
DOI:10.1021/ol4003948

Reference yield:

: 1426342-06-4
(3S,3aS)-5,5-dibutyl-3a-hydroxymethyl-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole

: 1426341-82-3
(3S,3aR)-3a-(methoxymethyl)-3-phenyl-2-tosyl-2,3,3a,4-tetrahydro-1H-benzo[f]isoindole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / hexane; tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 18 h / 0 - 20 °C / Inert atmosphere

2.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; 1,4-diaza-bicyclo[2.2.2]octane / 1,4-dioxane / 20 h / Inert atmosphere; Reflux

With 1,4-diaza-bicyclo[2.2.2]octane; bis(tri-t-butylphosphine)palladium⁽⁰⁾; sodium hydride; In tetrahydrofuran; 1,4-dioxane; hexane;
DOI:10.1021/ol4003948

Reference yield:

: 1383438-14-9
(3S,3aS)-tert-butyl 5,5-dibutyl-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole-3a-carboxylate

: 1426341-82-3
(3S,3aR)-3a-(methoxymethyl)-3-phenyl-2-tosyl-2,3,3a,4-tetrahydro-1H-benzo[f]isoindole

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / dichloromethane / 3.5 h / -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / hexane; tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

2.2: 18 h / 0 - 20 °C / Inert atmosphere

3.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; 1,4-diaza-bicyclo[2.2.2]octane / 1,4-dioxane / 20 h / Inert atmosphere; Reflux

With 1,4-diaza-bicyclo[2.2.2]octane; bis(tri-t-butylphosphine)palladium⁽⁰⁾; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;
DOI:10.1021/ol4003948