(3S,3aS)-5,5-dibutyl-3a-(methoxymethyl)-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole

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Chemical Name:(3S,3aS)-5,5-dibutyl-3a-(methoxymethyl)-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole
CAS No.:1426342-12-2
Molecular Formula:C₂₉H₄₁NO₃SSn
Molecular Weight:602.425
Hs Code.:

Synonyms:(3S,3aS)-5,5-dibutyl-3a-(methoxymethyl)-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole

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Chemical Property of (3S,3aS)-5,5-dibutyl-3a-(methoxymethyl)-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole

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Technology Process of (3S,3aS)-5,5-dibutyl-3a-(methoxymethyl)-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole

There total 2 articles about (3S,3aS)-5,5-dibutyl-3a-(methoxymethyl)-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1426342-06-4
(3S,3aS)-5,5-dibutyl-3a-hydroxymethyl-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole

: 74-88-4
methyl iodide

: 1426342-12-2
(3S,3aS)-5,5-dibutyl-3a-(methoxymethyl)-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole

Guidance literature:: (3S,3aS)-5,5-dibutyl-3a-hydroxymethyl-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole; With sodium hydride; In tetrahydrofuran; hexane; at 0 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ol4003948

Reference yield:

: 1383438-14-9
(3S,3aS)-tert-butyl 5,5-dibutyl-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole-3a-carboxylate

: 1426342-12-2
(3S,3aS)-5,5-dibutyl-3a-(methoxymethyl)-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / dichloromethane / 3.5 h / -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / hexane; tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

2.2: 18 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol4003948

Reference yield: 48.0%

: 1426342-12-2
(3S,3aS)-5,5-dibutyl-3a-(methoxymethyl)-3-phenyl-2-tosyl-1,2,3,3a,4,5-hexahydrostannolo[3,4-c]pyrrole

: 583-53-9
2,3-dibromobenzene

: 1426341-82-3
(3S,3aR)-3a-(methoxymethyl)-3-phenyl-2-tosyl-2,3,3a,4-tetrahydro-1H-benzo[f]isoindole

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; for 20h; Inert atmosphere; Reflux;
DOI:10.1021/ol4003948