1-{(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[ethyl-(2-ethylamino-ethyl)-amino]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-{(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[ethyl-(2-ethylamino-ethyl)-amino]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:177898-48-5
Molecular Formula:C₃₇H₄₆N₄O₆
Molecular Weight:642.795
Hs Code.:

1-{(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[ethyl-(2-ethylamino-ethyl)-amino]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Synonyms:1-{(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[ethyl-(2-ethylamino-ethyl)-amino]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-{(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[ethyl-(2-ethylamino-ethyl)-amino]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-{(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[ethyl-(2-ethylamino-ethyl)-amino]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

There total 1 articles about 1-{(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[ethyl-(2-ethylamino-ethyl)-amino]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 111-74-0
N,N'-diethylethylenediamine

: 143527-01-9
1-(2'-deoxy-3'-O-mesyl-5'-O-4,4'-dimethoxytrityl-β-D-threo-pentofuranosyl)-thymine

: 177898-48-5
1-{(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[ethyl-(2-ethylamino-ethyl)-amino]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With pyridine; at 150 ℃; for 72h;
DOI:10.1016/0960-894X(96)00159-X

Reference yield: 81.0%

: 3544-99-8
thymidine-5'-carboxylic acid

: 177898-48-5
1-{(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[ethyl-(2-ethylamino-ethyl)-amino]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

: 177898-51-0
C₄₇H₅₆N₆O₁₁

Guidance literature:: With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at -20 - 25 ℃; for 60h;
DOI:10.1016/0960-894X(96)00159-X

Reference yield:

: 177898-48-5
1-{(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[ethyl-(2-ethylamino-ethyl)-amino]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

: C₅₆H₇₃N₈O₁₂P

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / dicyclohexylcarbodiimide, N-hydroxysuccinimide / dimethylformamide / 60 h / -20 - 25 °C

2: 72 percent / EtN(iPr)2 / CH₂Cl₂ / 1 h / Ambient temperature

With 1-hydroxy-pyrrolidine-2,5-dione; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00159-X