3544-99-8

Usage

Uses

Used in Pharmaceutical Research:
(2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolane-2-carboxylic acid is used as a compound of interest in pharmaceutical research for its potential biological activity. Its complex structure suggests that it could be instrumental in developing new drugs, making it a valuable asset in the search for novel therapeutic agents.
Used in Drug Discovery:
In the field of drug discovery, (2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolane-2-carboxylic acid is used as a lead compound. Its unique molecular features position it as a candidate for further exploration and optimization to create new pharmaceuticals that address unmet medical needs.
Further research is necessary to fully understand the capabilities and potential applications of (2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolane-2-carboxylic acid, as its biological activity and other properties are not yet fully known.

InChI:InChI=1/C10H12N2O6/c1-4-3-12(10(17)11-8(4)14)6-2-5(13)7(18-6)9(15)16/h3,5-7,13H,2H2,1H3,(H,15,16)(H,11,14,17)/t5-,6+,7-/m0/s1

Upstream product

• 67-56-1 methanol 
• 704883-64-7 thymidine-5'-carboxylic acid tert-butyl perester 

Downstream Products

• 80647-05-8 N-<4-<2-(chloromethyl)-1,3-dioxolan-2-yl>phenyl>-1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-β-D-erythro-pentofuranuronamide 
• 111087-12-8 1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-N-<4-(3-methylureido)phenyl>-β-D-ribofuranuronamide 
• 153765-12-9 4-<1,2-dideoxy-1-(thymin-1-yl)-β-D-ribofuranuronamido>-O-(4,4'-dimethoxytrityl) ethanol 
• 132376-92-2 <5'-(2)H2>thymidine 
• 168772-59-6 (2S,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-carboxylic acid {2-[(S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-ethoxy]-ethyl}-amide 
• 177898-49-6 C₄₆H₅₂N₆O₁₁ 
• 177898-51-0 C₄₇H₅₆N₆O₁₁ 
• 205580-01-4 (S)-5-Benzyloxycarbonylamino-2-{[(2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-carbonyl]-amino}-pentanoic acid benzyl ester 
• 80647-04-7 N-<4-(chloroacetyl)phenyl>-1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-β-D-erythro-pentofuranuronamide 
• 89196-52-1 N-<4-(bromoacetyl)phenyl>-1,2-dideoxy-1-<3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl>-β-D-erythro-pentofuranuronamide 

Relevant academic research and scientific papers

Thermal decomposition of the tert-butyl perester of thymidine-5′- carboxylic acid. Formation and fate of the pseudo-C4′ radical

Thermal decomposition of the tert-butyl perester of thymidine-5′- carboxylic acid 1 carried out at 85°C in different solvents affords the tert-butylacetal 4a, deriving from in cage decomposition, and pseudo C4′ radicals 2. Radicals 2 can be reduced to 5 by hydrogen atom abstraction from thiol (thiophenol or glutathione) or THF, or can be oxidized to cations 8 by dioxygen or perester 1 itself. Cations 8 are stereoselectively trapped by the nucleophilic solvent (tert-butanol, methanol, water) to give acetals 4a-c.