(S,S)-9,17-dibenzyl-1,4,7,13-tetraoxa-10,16-diazacyclo-octadecane-11,15-dione

Base Information

Chemical Name:(S,S)-9,17-dibenzyl-1,4,7,13-tetraoxa-10,16-diazacyclo-octadecane-11,15-dione
CAS No.:80757-20-6
Molecular Formula:C₂₆H₃₄N₂O₆
Molecular Weight:470.566
Hs Code.:

Synonyms:(S,S)-9,17-dibenzyl-1,4,7,13-tetraoxa-10,16-diazacyclo-octadecane-11,15-dione

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Chemical Property of (S,S)-9,17-dibenzyl-1,4,7,13-tetraoxa-10,16-diazacyclo-octadecane-11,15-dione

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Technology Process of (S,S)-9,17-dibenzyl-1,4,7,13-tetraoxa-10,16-diazacyclo-octadecane-11,15-dione

There total 6 articles about (S,S)-9,17-dibenzyl-1,4,7,13-tetraoxa-10,16-diazacyclo-octadecane-11,15-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 21062-20-4
diglycolyl chloride

: 80757-34-2
(2S,12S)-(-)-2,12-diamino-1,13-diphenyl-4,7,10-trioxatridecane

: 80757-20-6
(S,S)-9,17-dibenzyl-1,4,7,13-tetraoxa-10,16-diazacyclo-octadecane-11,15-dione

Guidance literature:: With triethylamine; In dichloromethane; toluene; for 20h;

Reference yield:

: 3182-93-2
(L)-phenylalanine ethyl ester hydrochloride

: 80757-20-6
(S,S)-9,17-dibenzyl-1,4,7,13-tetraoxa-10,16-diazacyclo-octadecane-11,15-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) TDI; 2.) Et₃N / 1.) THF, 30 min, RT, futher reag.; 2.) 20 h, RT

2: 87.8 percent / LiAlH₄ / tetrahydrofuran / -30 °C

3: 1.) NaH, DMSO; / 1.) 1 h, 70-75 deg C; 2.) 1 h, 45-50 deg C; 3.) RT, 7 h

With lithium aluminium tetrahydride; sodium hydride; dimethyl sulfoxide; triethylamine; 2,4-Toluene diisocyanate; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)86893-9

Reference yield:

: 83597-39-1
(S)-2-{2-[((S)-1-Ethoxycarbonyl-2-phenyl-ethylcarbamoyl)-methoxy]-acetylamino}-3-phenyl-propionic acid ethyl ester

: 80757-20-6
(S,S)-9,17-dibenzyl-1,4,7,13-tetraoxa-10,16-diazacyclo-octadecane-11,15-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 87.8 percent / LiAlH₄ / tetrahydrofuran / -30 °C

2: 1.) NaH, DMSO; / 1.) 1 h, 70-75 deg C; 2.) 1 h, 45-50 deg C; 3.) RT, 7 h

With lithium aluminium tetrahydride; sodium hydride; dimethyl sulfoxide; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)86893-9